Lauroylsarcosine, Sodium Salt (CAS 137-16-6)

Lauroylsarcosine, Sodium Salt, commonly known as LS, is a zwitterionic surfactant with a unique amphiphilic structure, making it a valuable tool in various scientific research domains. Its mechanism of action involves the disruption of lipid-protein interactions and solubilization of membrane proteins. LS has been extensively utilized in biochemistry and molecular biology for its ability to efficiently solubilize and extract membrane proteins from biological membranes, facilitating their purification and characterization. Furthermore, LS is employed in protein research for its compatibility with downstream analytical techniques such as chromatography and mass spectrometry. In addition to its role in membrane protein studies, LS finds applications in cell biology, where it is used to permeabilize cell membranes for intracellular delivery of macromolecules such as proteins and nucleic acids. Its mild detergent properties and low cytotoxicity make LS a preferred choice in cell culture experiments and in the preparation of functional lipid bilayers for biophysical studies. Ongoing research continues to explore novel applications and modifications of LS, underscoring its importance in advancing scientific understanding across various research disciplines.