Molecular structure of L-(−)-α-Methyldopa, CAS Number: 555-30-6
L-(−)-α-Methyldopa (CAS 555-30-6)
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Alternate Names:
MK-35; Baypresol; Hyperpax
Application:
L-(−)-α-Methyldopa is a DDC inhibitor and antihypertensive
CAS Number:
555-30-6
Purity:
≥98%
Molecular Weight:
211.22
Molecular Formula:
C10H13NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-(−)-α-Methyldopa is widely used in biochemical research, particularly in studies related to neurotransmitter synthesis and metabolism. This compound acts as a precursor in the biosynthesis of catecholamines, making it useful for understanding the enzymatic pathways involved in the production of these important neurotransmitters. Researchers employ L-(−)-α-Methyldopa to study its conversion to alpha-methyl norepinephrine within the central nervous system, which is for exploring mechanisms of neurotransmission. Additionally, it is utilized in investigations of enzyme activity, such as aromatic L-amino acid decarboxylase, and its regulation.
L-(−)-α-Methyldopa (CAS 555-30-6) References
- Stereospecificity of horseradish peroxidase. | Gilabert, MA., et al. 2004. Biol Chem. 385: 1177-84. PMID: 15653431
- Stereospecificity of mushroom tyrosinase immobilized on a chiral and a nonchiral support. | Marín-Zamora, ME., et al. 2007. J Agric Food Chem. 55: 4569-75. PMID: 17488091
- Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2). | Hu, M. and Borchardt, RT. 1990. Pharm Res. 7: 1313-9. PMID: 2095572
- Use of the peptide carrier system to improve the intestinal absorption of L-alpha-methyldopa: carrier kinetics, intestinal permeabilities, and in vitro hydrolysis of dipeptidyl derivatives of L-alpha-methyldopa. | Hu, M., et al. 1989. Pharm Res. 6: 66-70. PMID: 2717522
- Correlation between fall in blood pressure and in vivo amine release after alpha-methylDOPA. | Kapoor, V. and Chalmers, J. 1989. Eur J Pharmacol. 164: 531-8. PMID: 2767124
- The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. | Fox, GR. and Virgo, BB. 1985. Toxicol Appl Pharmacol. 78: 342-50. PMID: 4049384
- Further studies on the mechanism of the central hypotensive effect of L-dopa, DL-m-tyrosine and L-alpha-methyldopa. | Rubenson, A. 1971. J Pharm Pharmacol. 23: 228-30. PMID: 4396899
- Synthesis of L-alpha-methyldopa from asymmetric intermediates. | Reinhold, DF., et al. 1968. J Org Chem. 33: 1209-13. PMID: 5639346
- Hepatic injury caused by L-alpha-methyldopa. | Elkington, SG., et al. 1969. Circulation. 40: 589-95. PMID: 5823554
- The hypotensive activity and side effects of methyldopa, clonidine, and guanfacine. | van Zwieten, PA., et al. 1984. Hypertension. 6: II28-33. PMID: 6094346
- Metabolism of L-alpha-methyldopa in cultured human intestinal epithelial (Caco-2) cell monolayers. Comparison with metabolism in vivo. | Chikhale, PJ. and Borchardt, RT. 1994. Drug Metab Dispos. 22: 592-600. PMID: 7956735
- Intestinal absorption studies on peptide mimetic alpha-methyldopa prodrugs. | Wang, HP., et al. 1996. J Pharm Pharmacol. 48: 270-6. PMID: 8737052
- Study of stereospecificity in mushroom tyrosinase. | Espín, JC., et al. 1998. Biochem J. 331 (Pt 2): 547-51. PMID: 9531496
Inhibitor of:
DDC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-(−)-α-Methyldopa, 1 g | sc-203092 | 1 g | $31.00 | |||
L-(−)-α-Methyldopa, 5 g | sc-203092A | 5 g | $97.00 |