L-Leucyl-L-alanine (CAS 7298-84-2)
QUICK LINKS
L-Leucyl-L-alanine is a dipeptide found to inhibit ubiquitin-mediated protein degradation. It is used as fluorescence intensifier in fluorimetric methods for the determination of phenylalanine. L-Leucyl-L-alanine has been investigated through in vitro experiments to understand its effects on cell cultures, specifically its impact on cell growth and differentiation. Although the mechanism of action of L-Leucyl-L-alanine is not entirely understood, it is hypothesized to function as a substrate for enzymes that play a role in protein synthesis and energy metabolism. Additionally, it is thought to be involved in regulating gene expression and cell signaling pathways. Researchers have found that L-Leucyl-L-alanine has the ability to stimulate the production of cytokines, including interleukin-1β and tumor necrosis factor-α, which are essential in the immune response. Moreover, it has demonstrated antimicrobial properties against various bacteria, such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The compound has also been investigated for its potential as an anti-inflammatory agent.
L-Leucyl-L-alanine (CAS 7298-84-2) References
- Estimating the genetic divergence and identification of three Trichinella species by isoenzyme analysis. | Snábel, V., et al. 2001. Parasite. 8: S30-3. PMID: 11484377
- Effects of the combination of a proteasome inhibitor (PSI) and an inhibitor of ubiquitin-ligases (Leu-Ala) on the ultrastructure of human leukemic U937 cells. | Biały, LP., et al. 2002. Folia Histochem Cytobiol. 40: 135-6. PMID: 12056612
- Expression, purification, and characterization of minimized chicken riboflavin carrier protein from a synthetic gene in Escherichia coli. | Subramanian, S., et al. 2002. Protein Expr Purif. 26: 284-9. PMID: 12406683
- [Racemic splitting of esters of valyl-glycine, leucyl-glycine & alanyl-beta-alanine]. | LOSSE, G., et al. 1959. Hoppe Seylers Z Physiol Chem. 314: 224-33. PMID: 13664211
- The development of VIP-ellipticine conjugates. | Moody, TW., et al. 2004. Regul Pept. 123: 187-92. PMID: 15518911
- Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. | Ghosh, AK., et al. 2007. J Med Chem. 50: 2399-407. PMID: 17432843
- Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. | Ghosh, AK., et al. 2008. Bioorg Med Chem Lett. 18: 1031-6. PMID: 18180160
- Construction of covalently coupled, concatameric dimers of 7TM receptors. | Terpager, M., et al. 2009. J Recept Signal Transduct Res. 29: 235-45. PMID: 19747085
- Antimicrobial metabolites from a novel halophilic actinomycete Nocardiopsis terrae YIM 90022. | Tian, S., et al. 2014. Nat Prod Res. 28: 344-6. PMID: 24236566
- Genetic variation of peptidase and pyrophosphatase in the chicken. | Lundin, LG. and Wilhelmson, M. 1989. Poult Sci. 68: 1313-8. PMID: 2555801
- Potent complement C3a receptor agonists derived from oxazole amino acids: Structure-activity relationships. | Singh, R., et al. 2015. Bioorg Med Chem Lett. 25: 5604-8. PMID: 26522948
- Purification and identification of anti-inflammatory peptides derived from simulated gastrointestinal digests of velvet antler protein (Cervus elaphus Linnaeus). | Zhao, L., et al. 2016. J Food Drug Anal. 24: 376-384. PMID: 28911592
- Sites of dipeptide hydrolysis in relation to sites of histidine and glucose active transport in hamster intestine. | Wiseman, G. 1983. J Physiol. 342: 421-35. PMID: 6631743
- Isolation and structure elucidation of two new calpain inhibitors from Streptomyces griseus. | Alvarez, ME., et al. 1994. J Antibiot (Tokyo). 47: 1195-201. PMID: 8002381
- Analysis of aminopeptidase and dipeptidylpeptidase IV from the entomopathogenic fungus Metarhizium anisopliae. | St Leger, RJ., et al. 1993. J Gen Microbiol. 139: 237-43. PMID: 8094738
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Leucyl-L-alanine, 1 g | sc-300885 | 1 g | $90.00 | |||
L-Leucyl-L-alanine, 5 g | sc-300885A | 5 g | $235.00 | |||
L-Leucyl-L-alanine, 25 g | sc-300885B | 25 g | $999.00 | |||
L-Leucyl-L-alanine, 100 g | sc-300885C | 100 g | $3860.00 |