Date published: 2025-12-5

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L-cis-Diltiazem hydrochloride (CAS 42399-54-2)

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Application:
L-cis-Diltiazem hydrochloride is a calcium channel protein inhibitor
CAS Number:
42399-54-2
Purity:
≥98%
Molecular Weight:
451.0
Molecular Formula:
C22H26N2O4S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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L-cis-Diltiazem hydrochloride is a chemical compound primarily known for its ability to inhibit calcium ion influx across cell membranes, with a specific affinity for voltage-dependent calcium channels. This unique mechanism of action makes it an invaluable tool in research focused on understanding calcium channel dynamics and their role in cellular processes. Its ability to modulate calcium channel activity allows for the study of various physiological and pathophysiological states in cellular models, providing insights into the regulation of intracellular calcium levels. This modulation is for investigating the intricate balance of calcium ions in cellular signaling, muscle contraction, and neurotransmitter release. By selectively inhibiting these channels, L-cis-Diltiazem hydrochloride offers researchers a precise method to dissect the complex role of calcium ions in cellular function.


L-cis-Diltiazem hydrochloride (CAS 42399-54-2) References

  1. Both D-cis- and L-cis-diltiazem attenuate hydrogen peroxide-induced derangements in rat hearts.  |  Xiao, CY., et al. 1999. Eur J Pharmacol. 374: 387-98. PMID: 10422783
  2. Spontaneous gating of olfactory cyclic-nucleotide-gated channels.  |  Kleene, SJ. 2000. J Membr Biol. 178: 49-54. PMID: 11058687
  3. NO upregulation of a cyclic nucleotide-gated channel contributes to calcium elevation in endothelial cells.  |  Zhang, J., et al. 2002. Am J Physiol Cell Physiol. 283: C1080-9. PMID: 12225972
  4. Odors detected by mice deficient in cyclic nucleotide-gated channel subunit A2 stimulate the main olfactory system.  |  Lin, W., et al. 2004. J Neurosci. 24: 3703-10. PMID: 15071119
  5. Atrial natriuretic peptide and cGMP activate sodium transport through PKA-dependent pathway in the urinary bladder of the Japanese tree frog.  |  Yamada, T., et al. 2006. J Comp Physiol B. 176: 203-12. PMID: 16320061
  6. Cyclic nucleotide-gated channels are involved in phototransduction of dermal photoreceptors in Lymnaea stagnalis.  |  Pankey, S., et al. 2010. J Comp Physiol B. 180: 1205-11. PMID: 20567976
  7. Enhanced alveolar fluid clearance following 72 h of continuous isoproterenol infusion in rats.  |  Pedersen, LR., et al. 2012. Acta Physiol (Oxf). 206: 142-9. PMID: 22681716
  8. Mouse Grueneberg ganglion neurons share molecular and functional features with C. elegans amphid neurons.  |  Brechbühl, J., et al. 2013. Front Behav Neurosci. 7: 193. PMID: 24367309
  9. Transduction for pheromones in the main olfactory epithelium is mediated by the Ca2+ -activated channel TRPM5.  |  López, F., et al. 2014. J Neurosci. 34: 3268-78. PMID: 24573286

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

L-cis-Diltiazem hydrochloride, 5 mg

sc-221802
5 mg
$207.00