L-364,373 (CAS 103342-82-1)
Available in US only.
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L-364,373 is a chemical compound used in research focused on the study of benzodiazepine receptors and their associated activites. Due to its specific structure, it is of interest in the exploration of the GABA(A) receptor subtypes and their binding affinities. In neurochemistry, L-364,373 is utilized to investigate the modulation of neurotransmitter systems, particularly the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), and its role in neurological processes. The compound is also valuable in the study of anxiolytic and sedative effects at the molecular level, as it informs the design of ligands with potential selectivity for different benzodiazepine receptor subpopulations. Moreover, in the field of synthetic organic chemistry, L-364,373 is a target for synthetic pathway development, allowing researchers to refine techniques for constructing complex molecules such as 1,4-benzodiazepin-2-ones. The interactions of L-364,373 with various receptor isoforms can shed light on the structural requirements for binding and activity, contributing to the broader understanding of receptor-ligand interactions.
L-364,373 (CAS 103342-82-1) References
- Modulation and genetic identification of the M channel. | Brown, BS. and Yu, SP. 2000. Prog Biophys Mol Biol. 73: 135-66. PMID: 10958929
- L-364,373 fails to activate the slow delayed rectifier K+ current in canine ventricular cardiomyocytes. | Magyar, J., et al. 2006. Naunyn Schmiedebergs Arch Pharmacol. 373: 85-9. PMID: 16544107
- Rb+ efflux through functional activation of cardiac KCNQ1/minK channels by the benzodiazepine R-L3 (L-364,373). | Jow, F., et al. 2006. Assay Drug Dev Technol. 4: 443-50. PMID: 16945016
- Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes. | Nissen, JD., et al. 2009. J Cardiovasc Pharmacol. 54: 169-77. PMID: 19568177
- AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells. | Alzamora, R., et al. 2010. Am J Physiol Renal Physiol. 299: F1308-19. PMID: 20861072
- K+ channels regulate ENaC expression via changes in promoter activity and control fluid clearance in alveolar epithelial cells. | Bardou, O., et al. 2012. Biochim Biophys Acta. 1818: 1682-90. PMID: 22406554
- Functional expression of KCNQ (Kv7) channels in guinea pig bladder smooth muscle and their contribution to spontaneous activity. | Anderson, UA., et al. 2013. Br J Pharmacol. 169: 1290-304. PMID: 23586426
- Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. | Yu, H., et al. 2013. Proc Natl Acad Sci U S A. 110: 8732-7. PMID: 23650380
- L-364,373 (R-L3) enantiomers have opposite modulating effects on IKs in mammalian ventricular myocytes. | Corici, C., et al. 2013. Can J Physiol Pharmacol. 91: 586-92. PMID: 23889560
- Molecular basis of potassium channels in pancreatic duct epithelial cells. | Hayashi, M. and Novak, I. 2013. Channels (Austin). 7: 432-41. PMID: 23962792
- Molecular expression and pharmacological evidence for a functional role of kv7 channel subtypes in Guinea pig urinary bladder smooth muscle. | Afeli, SA., et al. 2013. PLoS One. 8: e75875. PMID: 24073284
- Kv7 channels critically determine coronary artery reactivity: left-right differences and down-regulation by hyperglycaemia. | Morales-Cano, D., et al. 2015. Cardiovasc Res. 106: 98-108. PMID: 25616413
- Lean and Obese Coronary Perivascular Adipose Tissue Impairs Vasodilation via Differential Inhibition of Vascular Smooth Muscle K+ Channels. | Noblet, JN., et al. 2015. Arterioscler Thromb Vasc Biol. 35: 1393-400. PMID: 25838427
- Kv7 potassium channels as signal transduction intermediates in the control of microvascular tone. | Byron, KL. and Brueggemann, LI. 2018. Microcirculation. 25: PMID: 28976052
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-364,373, 2.5 mg | sc-204036 | 2.5 mg | $245.00 | |||
| US: Only available in the US | ||||||
L-364,373, 5 mg | sc-204036B | 5 mg | $478.00 | |||
| US: Only available in the US | ||||||
L-364,373, 10 mg | sc-204036C | 10 mg | $895.00 | |||
| US: Only available in the US | ||||||