KIF15 Antibody (36-I): sc-100948

KIF15 Antibody (36-I) is a mouse monoclonal IgG2b kappa light chain antibody that detects the KIF15 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-KIF15 antibody (36-I) is available as the non-conjugated format. KIF15, also known as kinesin family member 15 or HKLP2, is a 1,388 amino acid kinesin-related protein that plays a pivotal role in cellular processes, particularly during cell division. KIF15 is essential for the proper organization and function of the mitotic spindle, as KIF15 is involved in the crosslinking and stabilization of spindle microtubules, which is crucial for accurate chromosome segregation. KIF15′s localization varies throughout the cell cycle; during prometaphase to early anaphase, KIF15 is found at spindle poles and along microtubules, while in cytokinesis, KIF15 localizes to the actin-based cleavage furrow. In postmitotic neurons, KIF15 is exclusively associated with microtubules, highlighting KIF15′s importance in maintaining neuronal structure and function. KIF15′s ability to interact with other proteins involved in microtubule dynamics further underscores KIF15′s significance in intracellular transport and cellular organization, making anti-KIF15 antibody (36-I) a valuable tool for researchers studying these critical biological processes.

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KIF15 Antibody (36-I) References:

1. Molecular motors and their role in membrane traffic.  |  Hamm-Alvarez, SF. 1998. Adv Drug Deliv Rev. 29: 229-242. PMID: 10837592
2. The forkhead-associated domain of Ki-67 antigen interacts with the novel kinesin-like protein Hklp2.  |  Sueishi, M., et al. 2000. J Biol Chem. 275: 28888-92. PMID: 10878014
3. Molecular cloning and functional analysis of mouse C-terminal kinesin motor KifC3.  |  Yang, Z., et al. 2001. Mol Cell Biol. 21: 765-70. PMID: 11154264
4. Kinesin-II, the heteromeric kinesin.  |  Cole, DG. 1999. Cell Mol Life Sci. 56: 217-26. PMID: 11212349
5. A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis.  |  Takagi, M., et al. 2001. J Biol Chem. 276: 25386-91. PMID: 11342549
6. repp86: A human protein associated in the progression of mitosis.  |  Heidebrecht, HJ., et al. 2003. Mol Cancer Res. 1: 271-9. PMID: 12612055
7. Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development.  |  Buster, DW., et al. 2003. J Neurocytol. 32: 79-96. PMID: 14618103
8. Inhibitors of mitotic kinesins: next-generation antimitotics.  |  Sarli, V. and Giannis, A. 2006. ChemMedChem. 1: 293-8. PMID: 16892362
9. KIF15-Mediated Stabilization of AR and AR-V7 Contributes to Enzalutamide Resistance in Prostate Cancer.  |  Gao, L., et al. 2021. Cancer Res. 81: 1026-1039. PMID: 33277366
10. Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis.  |  Zou, YJ., et al. 2022. Cell Mol Life Sci. 79: 422. PMID: 35835966
11. KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer.  |  Quan, G., et al. 2023. Cell Death Dis. 14: 137. PMID: 36807568
12. Kif15 deficiency contributes to depression-like behavior in mice.  |  Wang, J., et al. 2023. Metab Brain Dis. 38: 2369-2381. PMID: 37256467

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-KIF15 Antibody (36-I) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-KIF15 Antibody (36-I) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

KIF15 Antibody (36-I) Specifications

Alternate Product Name: KIF15

Product Clone Name: 36-I

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1279-1386

Epitope Target: KIF15

Epitope Species: human

Product Reactivity/Detection: KIF15

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for KIF15 Antibody (36-I): N/A