KF 38789 (CAS 257292-29-8)

KF 38789 is a potent and selective inhibitor of phosphodiesterase 4 (PDE4), an enzyme critical in the breakdown of cyclic adenosine monophosphate (cAMP) within cells. By inhibiting PDE4, KF 38789 leads to an increase in cAMP levels, which plays a pivotal role in modulating cellular responses to various stimuli, including inflammatory and immune responses. This mechanism of action makes KF 38789 useful in research focused on understanding the regulation of cAMP in various cellular processes, including inflammation, cell proliferation, and differentiation. Its selectivity for PDE4 over other phosphodiesterase isoenzymes allows for more precise investigations into the specific roles of PDE4 in cellular signaling pathways, providing insights into the underlying mechanisms of a wide range of physiological and pathological processes. Consequently, KF 38789 is widely used in the study of diseases characterized by dysregulated cAMP signaling pathways, facilitating the exploration of novel therapeutic targets and the development of cAMP-based strategies for disease modulation.