K-cadherin Antibody (5F95): sc-71462
- K-cadherin Antibody (5F95) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against the extracellular domain of K-cadherin of human origin
- recommended for detection of K-cadherin of mouse, rat and human origin by WB, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for K-cadherin Antibody (5F95). This work is in progress.
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K-cadherin Antibody (5F95) is a mouse monoclonal IgG1 antibody that detects K-cadherin in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and immunohistochemistry. K-cadherin, a member of the cadherin family, plays a crucial role in mediating cell-cell adhesion, which is essential for maintaining tissue integrity and facilitating morphogenetic processes. Anti-K-cadherin antibody (5F95) recognizes proteins primarily located at the cell membrane, where K-cadherin forms adherens junctions that connect adjacent cells, thereby contributing to the structural stability of tissues. Proper localization of K-cadherin is vital, as disruptions in expression or function can lead to various pathological conditions, including cancer metastasis and developmental disorders. K-cadherin′s extracellular domain is characterized by a series of five homologous repeats, which are critical for adhesive properties, while its intracellular domain interacts with cytoplasmic proteins like β-catenin, linking K-cadherin to the actin cytoskeleton and influencing cellular signaling pathways. K-cadherin monoclonal antibody (5F95) serves as an invaluable tool for researchers studying the dynamics of cell adhesion and the implications of cadherin function in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
K-cadherin Antibody (5F95) References:
- Alterations in expression of cadherin-6 and E-cadherin during kidney development and in renal cell carcinoma. | Shimazui, T., et al. 2000. Eur Urol. 38: 331-8. PMID: 10940709
- Cadherin 6 has a functional role in platelet aggregation and thrombus formation. | Dunne, E., et al. 2012. Arterioscler Thromb Vasc Biol. 32: 1724-31. PMID: 22539596
- Involvement of orphan nuclear receptor COUP-TFII in cadherin-6 and cadherin-11 regulation: implications in development and cancer. | Bringuier, PP., et al. 2015. Mech Dev. 136: 64-72. PMID: 25687954
- The Role of Wnt/β-Catenin Signaling and K-Cadherin in the Regulation of Intraocular Pressure. | Webber, HC., et al. 2018. Invest Ophthalmol Vis Sci. 59: 1454-1466. PMID: 29625468
- Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma. | Ma, C., et al. 2018. Oncol Lett. 15: 9498-9506. PMID: 29805672
- Characterization of the role for cadherin 6 in the regulation of human endometrial receptivity. | Zhou, W., et al. 2020. Reprod Biol Endocrinol. 18: 66. PMID: 32600462
- High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. | Zhao, Z., et al. 2021. Cancer Cell Int. 21: 493. PMID: 34530820
- Relationship between serum cadherin 6 and 11 levels and severe and early-onset preeclampsia: A pilot study. | Güvey, H., et al. 2022. Turk J Obstet Gynecol. 19: 104-110. PMID: 35770490
- Cadherin-6 is a novel mediator for the migration of mesenchymal stem cells to glioblastoma cells in response to stromal cell-derived factor-1. | Park, A., et al. 2024. FEBS Open Bio. 14: 1192-1204. PMID: 38719785
- Regulated expression of cadherin-6 and cadherin-11 in the glandular epithelial and stromal cells of the human endometrium. | Getsios, S., et al. 1998. Dev Dyn. 211: 238-47. PMID: 9520111
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
K-cadherin Antibody (5F95) | sc-71462 | 100 µg/ml | $322.00 |