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JTE 013 (CAS 383150-41-2)

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Alternate Names:
1-[1,3-Dimethyl-4-(2-methylethyl)-1H-pyrazolo[3,4-b]pyridin-6-yl]-4-(2,6-dichloro-4-pyridinyl)-semicarbazide
Application:
JTE 013 is an EDG-5 receptor antagonist
CAS Number:
383150-41-2
Purity:
≥98%
Molecular Weight:
408.29
Molecular Formula:
C17H19N7OCl2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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JTE 013 is a chemical that functions as a selective antagonist of the adenosine A2A receptor. It acts by binding to the A2A receptor and inhibiting its activation by adenosine, thereby blocking the downstream signaling pathways associated with this receptor. Jte 013′s mechanism of action involves targeting the adenosine A2A receptor and preventing its interaction with endogenous ligands. By doing so, it modulates the cellular responses mediated by this receptor, influencing various physiological processes. Development setting, JTE 013′s function lies in its ability to selectively block the adenosine A2A receptor, allowing for the investigation of the receptor′s role in different biological pathways. Its mechanism of action at the molecular level involves interfering with the binding of adenosine to the A2A receptor, thereby altering the downstream signaling. Jte 013′s functional role in experimental applications revolves around its specific interaction with the adenosine A2A receptor, providing insights into the receptor′s involvement in various cellular processes.


JTE 013 (CAS 383150-41-2) References

  1. Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.  |  Li, C., et al. 2012. J Neurophysiol. 108: 1473-83. PMID: 22673325
  2. Tumor Necrosis Factor-induced Decrease of Cochlear Blood Flow Can Be Reversed by Etanercept or JTE-013.  |  Sharaf, K., et al. 2016. Otol Neurotol. 37: e203-8. PMID: 27295443
  3. The role of sphingosine 1-phosphate receptor 2 in bile-acid-induced cholangiocyte proliferation and cholestasis-induced liver injury in mice.  |  Wang, Y., et al. 2017. Hepatology. 65: 2005-2018. PMID: 28120434
  4. Blockage of sphingosine-1-phosphate receptor 2 attenuates allergic asthma in mice.  |  Park, SJ. and Im, DS. 2019. Br J Pharmacol. 176: 938-949. PMID: 30706444
  5. JTE-013 supplementation improves erectile dysfunction in rats with streptozotocin-induced type Ⅰ diabetes through the inhibition of the rho-kinase pathway, fibrosis, and apoptosis.  |  Liu, K., et al. 2020. Andrology. 8: 497-508. PMID: 31610097
  6. Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway.  |  Liu, Y. and Tie, L. 2019. BMC Cardiovasc Disord. 19: 279. PMID: 31791242
  7. S1PR2 inhibitors potently reverse 5-FU resistance by downregulating DPD expression in colorectal cancer.  |  Zhang, YH., et al. 2020. Pharmacol Res. 155: 104717. PMID: 32088343
  8. Topical Application of S1P2 Antagonist JTE-013 Attenuates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice.  |  Kang, J., et al. 2020. Biomol Ther (Seoul). 28: 537-541. PMID: 32487782
  9. Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 Inflammasome.  |  Hou, L., et al. 2020. Front Immunol. 11: 1149. PMID: 32695095
  10. S1PR2 Inhibition Attenuates Allergic Asthma Possibly by Regulating Autophagy.  |  Liu, H., et al. 2020. Front Pharmacol. 11: 598007. PMID: 33643037
  11. JTE-013 Alleviates Inflammatory Injury and Endothelial Dysfunction Induced by Sepsis In Vivo and In Vitro.  |  Xu, Q., et al. 2021. J Surg Res. 265: 323-332. PMID: 33971464
  12. The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism.  |  Pitman, MR., et al. 2022. Sci Rep. 12: 454. PMID: 35013382
  13. The S1PR2-CCL2-BDNF-TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia.  |  Arenas, YM., et al. 2022. Neuropathol Appl Neurobiol. 48: e12799. PMID: 35152448

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

JTE 013, 10 mg

sc-203615
10 mg
$195.00

Preciso de cotação desse produto o mais breve possível: JTE 013 (CAS 383150-41-2). A ser usado a fim de bloquear oo S1PR2 in vivo. agradeco

Asked by: JULIANA
Thank you for your question. Please contact one of our authorized distributors in Brazil for an accurate quote and product availability. Please note that this compound is for research use only, and we do not support or recommend it for in vivo research applications. A link to search for our distributors' contact information is provided below. https://www.scbt.com/scbt/resources/distributors
Answered by: Technical Support
Date published: 2017-10-02
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Rated 5 out of 5 by from Br nnertBr nnert, D. et al. (PubMed 26321412) used the S1PR2 inhibitor JTE 013 to demonstrate that sphingosine 1-phosphate regulates IL-8 expression and secretion via S1PR1 and S1PR2 receptors-mediated signaling in extravillous trophoblast derived HTR-8/SVneo cells. -SCBT Publication Review
Date published: 2015-01-18
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JTE 013 is rated 5.0 out of 5 by 1.
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