Molecular structure of Isogranulatimide, CAS Number: 244148-46-7
Isogranulatimide (CAS 244148-46-7)
Application:
Isogranulatimide is cell-permeable alkaloid that acts as a potent and ATP-competitive inhibitor of Chk1
CAS Number:
244148-46-7
Purity:
≥95%
Molecular Weight:
276.3
Molecular Formula:
C15H8N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A cell-permeable alkaloid containing indole/maleimide/imidazole skeleton that acts as a potent and ATP-competitive inhibitor of Chk1 (IC50 = 100 nM) and GSK-3b (IC50 = 500 nM). Inhibits G2 DNA damage checkpoint-associated kinases, Chk2, Cdk1, and DNA-PK only at much higher concentrations (IC50 = 3 µM, 10 µM, and 10 µM, respectively). Only minimally affects the activities of a panel of 11 other kinases tested (IC50 ≥ 40 µM). When used in combination with g-irradiation, it is also reported to selectively arrest the growth of MCF-7 cells lacking p53 function.
Isogranulatimide (CAS 244148-46-7) References
Jiang, X., et al. 2004. Mol. Cancer Ther. 3, 1221. Roberge, M., et al. 1998. Cancer Res. 58, 5701.Inhibitor of:
Cdk.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Isogranulatimide, 1 mg | sc-202667 | 1 mg | $700.00 |