Date published: 2026-5-12

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Ioxitalamic Acid (CAS 28179-44-4)

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Alternate Names:
3-(Acetylamino)-5-[[(2-hydroxyethyl)amino]carbonyl]-2,4,6-triiodobenzoic Acid; 3-Acetamido-2,4,6-triiodo-(N-β-hydroxyethyl)isophthalic Acid Monoamide
Application:
Ioxitalamic Acid is a contrast medium
CAS Number:
28179-44-4
Molecular Weight:
643.94
Molecular Formula:
C12H11I3N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ioxitalamic Acid, an organoiodine compound characterized by the substitution of an acetylamino group at position 3 and a (2-hydroxyethyl)carbamoyl group at position 5 on the 2,4,6-triiodobenzoic acid structure, is a highly effective contrast medium widely used in medical imaging. As an ionic iodinated contrast medium, it belongs to the first generation of contrast media and exists as an ionic monomer with a high osmolarity of 1500-1800 mOsm/kg. Ioxitalamic acid is available in the market as sodium and meglumine salts, which were developed by Liebel-Flarshem Canada Inc and approved by Health Canada in 1995. Despite being introduced earlier, it remains a viable option and continues to be accessible as of the last review conducted in 2015. Primarily used as a contrast medium, it serves roles as a xenobiotic, an environmental contaminant, and a radioopaque medium. Additionally, it is classified as a dicarboxylic acid monoamide and belongs to the group of acetamides, organoiodine compounds, and benzoic acids.


Ioxitalamic Acid (CAS 28179-44-4) References

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  2. Analysis of iodinated X-ray contrast agents in water samples by ion chromatography and inductively-coupled plasma mass spectrometry.  |  Sacher, F., et al. 2005. J Chromatogr A. 1085: 117-23. PMID: 16106857
  3. Analysis of drugs and personal care products in French source and drinking waters: the analytical challenge and examples of application.  |  Bruchet, A., et al. 2005. Water Sci Technol. 52: 53-61. PMID: 16312951
  4. Reducing micropollutants with source control: substance flow analysis of 212 pharmaceuticals in faeces and urine.  |  Lienert, J., et al. 2007. Water Sci Technol. 56: 87-96. PMID: 17881841
  5. Mass flows of X-ray contrast media and cytostatics in hospital wastewater.  |  Weissbrodt, D., et al. 2009. Environ Sci Technol. 43: 4810-7. PMID: 19673269
  6. Elimination of organic micropollutants in a municipal wastewater treatment plant upgraded with a full-scale post-ozonation followed by sand filtration.  |  Hollender, J., et al. 2009. Environ Sci Technol. 43: 7862-9. PMID: 19921906
  7. Relating environmental concentrations of pharmaceuticals to consumption: A mass balance approach for the river Rhine.  |  ter Laak, TL., et al. 2010. Environ Int. 36: 403-9. PMID: 20398939
  8. Elimination of micropollutants during post-treatment of hospital wastewater with powdered activated carbon, ozone, and UV.  |  Kovalova, L., et al. 2013. Environ Sci Technol. 47: 7899-908. PMID: 23758546
  9. Dual-wavelength recording, a simple algorithm to eliminate interferences due to UV-absorbing substances in capillary electrophoresis.  |  Seaux, L., et al. 2014. Electrophoresis. 35: 2248-52. PMID: 24981197
  10. A direct injection liquid chromatography tandem mass spectrometry method for the kinetic study on iodinated contrast media (ICMs) removal in natural water.  |  Lopez-Prieto, IJ., et al. 2020. Chemosphere. 243: 125311. PMID: 31759215
  11. [Comparative pharmacokinetics and renal accumulation of the iodized contrast media: ioxitalamic acid, ioxaglic acid and iohexol in the rabbit].  |  Morin, JP., et al. 1987. Pathol Biol (Paris). 35: 1215-20. PMID: 3320896
  12. Unravelling the contribution of nitrifying and methanotrophic bacteria to micropollutant co-metabolism in rapid sand filters.  |  Wang, J., et al. 2022. J Hazard Mater. 424: 127760. PMID: 34836694
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ioxitalamic Acid, 1 mg

sc-488522A
1 mg
$193.00

Ioxitalamic Acid, 2 mg

sc-488522B
2 mg
$245.00

Ioxitalamic Acid, 10 mg

sc-488522
10 mg
$317.00

Ioxitalamic Acid, 100 mg

sc-488522C
100 mg
$723.00

Ioxitalamic Acid, 1 g

sc-488522D
1 g
$1879.00