IFN-γ/Interferon gamma Antibody (NYRmIFNγ): sc-73304
- IFN-γ/Interferon gamma Antibody (NYRmIFNγ) is a rat monoclonal IgG1 provided at 100 µg/ml
- raised against recombinant IFN-γ of mouse origin
- recommended for detection of IFN-γ of mouse origin by WB, IP, ICF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for IFN-γ/Interferon gamma Antibody (NYRmIFNγ). This work is in progress.
IFN-γ Antibody (NYRmIFNγ) is a rat monoclonal IgG1 antibody that detects interferon gamma (IFN-γ) in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IFN-γ plays a crucial role in the immune response, acting as a potent antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. IFN-γ modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby orchestrating a balanced immune response. The active form of IFN-γ is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and functionality is further enhanced by various post-translational modifications, including glycosylation, leading to the existence of multiple forms under non-denaturing conditions, such as dimers and tetramers. The versatility of IFN-γ in immune regulation underscores its significance in therapeutic applications and research, making anti-IFN-γ antibody (NYRmIFNγ) an essential tool for studying immune responses in mouse models.
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IFN-γ/Interferon gamma Antibody (NYRmIFNγ) References:
- A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis. | Klunker, S., et al. 2003. J Immunol. 171: 1078-84. PMID: 12847282
- Selective roles of MAPKs during the macrophage response to IFN-gamma. | Valledor, AF., et al. 2008. J Immunol. 180: 4523-9. PMID: 18354174
- T-cell activation under hypoxic conditions enhances IFN-gamma secretion. | Roman, J., et al. 2010. Am J Respir Cell Mol Biol. 42: 123-8. PMID: 19372249
- Characterization of Trex1 induction by IFN-γ in murine macrophages. | Serra, M., et al. 2011. J Immunol. 186: 2299-308. PMID: 21239708
- Chronic inflammatory IFN-γ signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis. | Lüth, S., et al. 2011. Cancer Res. 71: 3763-71. PMID: 21512142
- Posttranscriptional regulation of IL-23 expression by IFN-gamma through tristetraprolin. | Qian, X., et al. 2011. J Immunol. 186: 6454-64. PMID: 21515794
- Airway IFN-γ production during RSV bronchiolitis is associated with eosinophilic inflammation. | Kim, CK., et al. 2012. Lung. 190: 183-8. PMID: 22160185
- Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ Production. | Zhan, Y., et al. 2016. J Immunol. 196: 5121-9. PMID: 27183588
- A fumigaclavine C isostere alleviates Th1-mediated experimental colitis via competing with IFN-γ for binding to IFN-γ receptor 1. | Tan, Y., et al. 2017. Biochem Pharmacol. 123: 63-72. PMID: 27751819
- Enumeration of IFN-gamma producing lymphocytes by flow cytometry and correlation with quantitative measurement of IFN-gamma. | Vikingsson, A., et al. 1994. J Immunol Methods. 173: 219-28. PMID: 7913946
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IFN-γ/Interferon gamma Antibody (NYRmIFNγ) | sc-73304 | 100 µg/ml | $316.00 |