IDH3G Antibody (C-8): sc-398066

IDH3G Antibody (C-8) is a mouse monoclonal IgM antibody that detects IDH3G of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-IDH3G antibody (C-8) is available in a non-conjugated form, providing flexibility for various experimental needs. IDH3G, or isocitrate dehydrogenase [NAD] subunit g (mitochondrial), is a crucial 393 amino acid protein encoded by the human gene IDH3G, which plays a vital role in cellular metabolism. IDH3G is part of the isocitrate and isopropylmalate dehydrogenases family and is typically located in the mitochondrion, where IDH3G functions as a heterooligomer composed of subunits α, β, and γ in a 2:1:1 ratio. IDH3G acts as a NAD-dependent enzyme in the tricarboxylic acid cycle, catalyzing the conversion of isocitrate to 2-oxoglutarate, a key intermediate essential for various metabolic pathways, including the glutamine synthetase/glutamate synthase cycle, which is critical for ammonium assimilation. IDH3G is allosterically activated by ADP, which enhances affinity for isocitrate, thereby regulating energy production in response to cellular energy demands, making IDH3G a pivotal enzyme in metabolism and a potential target for studying metabolic disorders and mitochondrial dysfunction.

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IDH3G Antibody (C-8) References:

1. Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness.  |  Perry, MC., et al. 2014. Mol Endocrinol. 28: 2060-71. PMID: 25361393
2. Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.  |  Landi, A., et al. 2014. Retrovirology. 11: 118. PMID: 25496667
3. Cerebrospinal fluid metabolomics identifies a key role of isocitrate dehydrogenase in bipolar disorder: evidence in support of mitochondrial dysfunction hypothesis.  |  Yoshimi, N., et al. 2016. Mol Psychiatry. 21: 1504-1510. PMID: 26782057
4. β-Cell deletion of Nr4a1 and Nr4a3 nuclear receptors impedes mitochondrial respiration and insulin secretion.  |  Reynolds, MS., et al. 2016. Am J Physiol Endocrinol Metab. 311: E186-201. PMID: 27221116
5. BZW2 Modulates Lung Adenocarcinoma Progression through Glycolysis-Mediated IDH3G Lactylation Modification.  |  Wang, M., et al. 2023. J Proteome Res. 22: 3854-3865. PMID: 37955350
6. Transcriptomic analysis identifies the shared diagnostic biomarkers and immune relationship between Atherosclerosis and abdominal aortic aneurysm based on fatty acid metabolism gene set.  |  Gu, X., et al. 2024. Front Mol Biosci. 11: 1365447. PMID: 38660376
7. A transcriptional regulatory mechanism of genes in the tricarboxylic acid cycle in the heart.  |  Veera, S., et al. 2024. J Biol Chem. 300: 107677. PMID: 39151728
8. Loss of glucose-stimulated β-cell Nr4a1 expression impairs insulin secretion and glucose homeostasis.  |  Herring, JA., et al. 2024. Am J Physiol Cell Physiol. 327: C1111-C1124. PMID: 39219449
9. Identification and validation of Atp5f1c in CD4+ T cell as a hub protein in Parkinson's disease.  |  Wang, G., et al. 2025. Int J Biol Macromol. 297: 139858. PMID: 39814280
10. Supplementation with N-Acetyl-L-cysteine during in vitro maturation improves goat oocyte developmental competence by regulating oxidative stress.  |  Wang, Y., et al. 2025. Theriogenology. 235: 221-230. PMID: 39855039

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IDH3G Antibody (C-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-IDH3G Antibody (C-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IDH3G Antibody (C-8) Specifications

Alternate Product Name: IDH3G

Product Clone Name: C-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 119-156

Epitope Target: IDH3G

Epitope Species: human

Product Reactivity/Detection: IDH3G

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for IDH3G Antibody (C-8): P: Blocking Peptide

The preferred IDH3G antibody is IDH3G Antibody (C-5): sc-365489.