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ID 8 has been shown to sustain self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Additional studies have shown that ID 8 stimulates proliferation at a steady rate.
1. Miyabayashi, Tomoyuki., et al., 2008. Indole derivatives sustain embryonic stem cell self-renewal in long-term culture. Bioscience, biotechnology, and biochemistry. 72(5): 1242-8. PMID: 18460821
2. Firestone, Ari J., et al., 2010. Controlling destiny through chemistry: small-molecule regulators of cell fate. ACS chemical biology. 5(1): 15-34. PMID: 20000447
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