Date published: 2026-4-25

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ID 8 (CAS 147591-46-6)

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Alternate Names:
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
Application:
ID 8 is which sustains self-renewal and pluripotency of mouse ESCs
CAS Number:
147591-46-6
Molecular Weight:
298.29
Molecular Formula:
C16H14N2O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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ID 8, a potent chemical compound, has garnered significant attention in scientific research due to its profound impact on cellular signaling pathways. With its unique mechanism of action, ID 8 serves as an invaluable tool for elucidating complex molecular mechanisms within cells. Research investigations have revealed that ID 8 acts as a modulator of key signaling cascades, particularly those involved in cell proliferation and differentiation. Its precise mode of action involves the modulation of intracellular signaling proteins, thereby influencing critical cellular processes. Furthermore, studies have demonstrated the ability of ID 8 to enhance cellular responses to external stimuli, facilitating a deeper understanding of cellular communication networks. In addition, ID 8 has been instrumental in uncovering novel pathways implicated in various physiological and pathological conditions. Its versatility as a research reagent extends to exploring the regulatory mechanisms of gene expression and protein function. Through its targeted manipulation of cellular signaling, ID 8 opens new avenues for investigating the underlying molecular events governing cellular behavior. Its widespread utilization across diverse research disciplines underscores its significance as a potent tool for unraveling the complexities of cellular biology and signaling pathways, paving the way for innovative discoveries in basic science research.


ID 8 (CAS 147591-46-6) References

  1. Molecular pathways involved in response to ionizing radiation of ID-8 mouse ovarian cancer cells expressing exogenous full-length Brca1 or truncated Brca1 mutant.  |  Sylvain, V., et al. 2001. Int J Oncol. 19: 599-607. PMID: 11494042
  2. Indole derivatives sustain embryonic stem cell self-renewal in long-term culture.  |  Miyabayashi, T., et al. 2008. Biosci Biotechnol Biochem. 72: 1242-8. PMID: 18460821
  3. Controlling destiny through chemistry: small-molecule regulators of cell fate.  |  Firestone, AJ. and Chen, JK. 2010. ACS Chem Biol. 5: 15-34. PMID: 20000447
  4. Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.  |  Hasegawa, K., et al. 2012. Stem Cells Transl Med. 1: 18-28. PMID: 23197636
  5. Inhibition properties of some flavonoids on carbonic anhydrase I and II isoenzymes purified from human erythrocytes.  |  Huyut, Z., et al. 2017. J Biochem Mol Toxicol. 31: PMID: 28445001
  6. Antioxidant and Antiradical Properties of Selected Flavonoids and Phenolic Compounds.  |  Huyut, Z., et al. 2017. Biochem Res Int. 2017: 7616791. PMID: 29158919
  7. A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation.  |  Monteiro, MB., et al. 2018. J Am Soc Nephrol. 29: 2820-2833. PMID: 30361326
  8. Chemically defined and growth-factor-free culture system for the expansion and derivation of human pluripotent stem cells.  |  Yasuda, SY., et al. 2018. Nat Biomed Eng. 2: 173-182. PMID: 31015717
  9. Updating dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2): molecular basis, functions and role in diseases.  |  Correa-Sáez, A., et al. 2020. Cell Mol Life Sci. 77: 4747-4763. PMID: 32462403
  10. Dual-specificity Tyrosine Phosphorylation-regulated Kinase Inhibitor ID-8 Promotes Human Somatic Cell Reprogramming by Activating PDK4 Expression.  |  Xu, J., et al. 2022. Stem Cell Rev Rep. 18: 2074-2087. PMID: 35080746

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

ID 8, 5 mg

sc-286015
5 mg
$78.00

ID 8, 25 mg

sc-286015A
25 mg
$315.00