ICOS Antibody (151-9): sc-53020
- ICOS Antibody (151-9) is a Syrian hamster monoclonal IgG provided at 200 µg/ml
- raised against the ectodomain of murine ICOS
- recommended for detection of ICOS of mouse origin by IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for ICOS Antibody (151-9). This work is in progress.
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ICOS Antibody (151-9) is a hamster monoclonal IgG antibody that detects ICOS in mouse samples through applications such as immunofluorescence (IF) and flow cytometry (FCM). ICOS, or inducible co-stimulator, plays a crucial role in T cell activation and regulation, functioning as a key player in the immune response. Located primarily on activated T cells, ICOS enhances T cell responses by promoting the production of cytokines, particularly interleukin-10, which is vital for maintaining immune homeostasis and preventing excessive inflammation. The interaction of ICOS with its ligand, B7h, is essential for the optimal activation of T cells, and its dysregulation can lead to autoimmune diseases or impaired immune responses. Anti-ICOS antibody (151-9) is an invaluable tool for researchers studying T cell biology and the mechanisms of immune regulation, providing insights into therapeutic strategies for various immunological disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ICOS Antibody (151-9) References:
- The role of ICOS and other costimulatory molecules in allergy and asthma. | Coyle, AJ. and Gutierrez-Ramos, JC. 2004. Springer Semin Immunopathol. 25: 349-59. PMID: 14999428
- Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation. | Guedan, S., et al. 2018. JCI Insight. 3: PMID: 29321369
- ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain. | O'Brien, CA. and Harris, TH. 2020. PLoS One. 15: e0228251. PMID: 31978191
- Role of endocytosis and trans-endocytosis in ICOS costimulator-induced downmodulation of the ICOS Ligand. | Aragoneses-Fenoll, L., et al. 2021. J Leukoc Biol. 110: 867-884. PMID: 33527556
- ICOS signaling limits regulatory T cell accumulation and function in visceral adipose tissue. | Mittelsteadt, KL., et al. 2021. J Exp Med. 218: PMID: 33881452
- Distinct roles of ICOS and CD40L in human T-B cell adhesion and antibody production. | Liu, Z., et al. 2021. Cell Immunol. 368: 104420. PMID: 34418679
- Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells. | Peng, C., et al. 2022. Immunity. 55: 98-114.e5. PMID: 34932944
- ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis. | Alves, GF., et al. 2022. Front Immunol. 13: 992614. PMID: 36119089
- PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during flu. | McGee, MC., et al. 2022. Front Immunol. 13: 984476. PMID: 36159872
- ICOS-expressing CAR-T cells mediate durable eradication of triple-negative breast cancer and metastasis. | Cao, L., et al. 2024. J Immunother Cancer. 12: PMID: 39532433
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ICOS Antibody (151-9) | sc-53020 | 200 µg/ml | $316.00 | |||
ICOS Antibody (151-9) FITC | sc-53020 FITC | 200 µg/ml | $330.00 | |||
ICOS Antibody (151-9) PE | sc-53020 PE | 200 µg/ml | $343.00 |