Date published: 2026-2-1

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Ibuprofen sodium salt (CAS 31121-93-4)

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Alternate Names:
α-Methyl-4-(isobutyl)phenylacetic acid
Application:
Ibuprofen sodium salt is A Cox inhibitor with greater activity against Cox-1 than Cox-2
CAS Number:
31121-93-4
Purity:
≥98%
Molecular Weight:
228.26
Molecular Formula:
C13H17O2•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ibuprofen sodium salt is widely studied in biochemical research for its enhanced aqueous solubility, which is in the design of high bioavailability formulations. In the domain of analytical chemistry, this salt form serves as a model compound for developing new quantification methods in complex biological matrices, given its distinct physicochemical properties. Researchers in the field of supramolecular chemistry are interested in how the ionic nature of ibuprofen sodium influences its interaction with cyclodextrins and other molecular hosts, which has implications for the creation of novel delivery mechanisms. Additionally, the compound′s predictable solvation dynamics are examined in physical chemistry to understand solute-solvent interactions. Ibuprofen sodium salt also provides a platform for studying the kinetics of dissolution and absorption without the confounding factors introduced by less soluble forms, thus contributing to the broader knowledge of how salt forms can modulate the behavior of active substances in various environments.


Ibuprofen sodium salt (CAS 31121-93-4) References

  1. Amphiphilic association of ibuprofen and two nonionic cellulose derivatives in aqueous solution.  |  Ridell, A., et al. 1999. J Pharm Sci. 88: 1175-81. PMID: 10564067
  2. Racemic species of sodium ibuprofen: characterization and polymorphic relationships.  |  Zhang, GG., et al. 2003. J Pharm Sci. 92: 1356-66. PMID: 12820140
  3. Initial salt screening procedures for manufacturing ibuprofen.  |  Lee, T. and Wang, YW. 2009. Drug Dev Ind Pharm. 35: 555-67. PMID: 19005918
  4. Bioavailability of ibuprofen following oral administration of standard ibuprofen, sodium ibuprofen or ibuprofen acid incorporating poloxamer in healthy volunteers.  |  Dewland, PM., et al. 2009. BMC Clin Pharmacol. 9: 19. PMID: 19961574
  5. Development of poly(glycerol adipate) nanoparticles loaded with non-steroidal anti-inflammatory drugs.  |  Wahab, A., et al. 2012. J Microencapsul. 29: 497-504. PMID: 22769722
  6. Composite films of poly(vinyl alcohol)-chitosan-bacterial cellulose for drug controlled release.  |  Pavaloiu, RD., et al. 2014. Int J Biol Macromol. 68: 117-24. PMID: 24769089
  7. Combined use of crystalline sodium salt and polymeric precipitation inhibitors to improve pharmacokinetic profile of ibuprofen through supersaturation.  |  Terebetski, JL., et al. 2014. AAPS PharmSciTech. 15: 1334-44. PMID: 24920524
  8. Combining ibuprofen sodium with cellulosic polymers: a deep dive into mechanisms of prolonged supersaturation.  |  Terebetski, JL. and Michniak-Kohn, B. 2014. Int J Pharm. 475: 536-46. PMID: 25219860
  9. On the molecular interaction between albumin and ibuprofen: An AFM and QCM-D study.  |  Eleta-Lopez, A., et al. 2015. Colloids Surf B Biointerfaces. 134: 355-62. PMID: 26218522
  10. Drug release kinetics from carboxymethylcellulose-bacterial cellulose composite films.  |  Juncu, G., et al. 2016. Int J Pharm. 510: 485-92. PMID: 26688041
  11. Glassy Dynamics and Translational-Rotational Coupling of an Ionically Conducting Pharmaceutical Salt-Sodium Ibuprofen.  |  Safna Hussan, KP., et al. 2019. J Phys Chem B. 123: 7764-7770. PMID: 31424212
  12. Influence of Polyvinyl Alcohol (PVA) on PVA-Poly-N-hydroxyethyl-aspartamide (PVA-PHEA) Microcrystalline Solid Dispersion Films.  |  Al-Sahaf, Z., et al. 2020. AAPS PharmSciTech. 21: 267. PMID: 33006710
  13. Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch.  |  Ossowicz-Rupniewska, P., et al. 2022. Int J Mol Sci. 23: PMID: 35887099

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ibuprofen sodium salt, 100 g

sc-252898
100 g
$201.00

Ibuprofen sodium salt, 500 g

sc-252898A
500 g
$733.00