HPV16 L2 Antibody (2JGmab#4): sc-65708
- HPV16 L2 Antibody (2JGmab#4) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-40 of HPV16 L2
- recommended for detection of L2 of HPV 16 origin by WB, IP and IF
- See HPV16 L2 (2JGmab#5): sc-65709 for HPV16 L2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HPV16 L2 Antibody (2JGmab#4). This work is in progress.
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HPV16 L2 Antibody (2JGmab#4) is a mouse monoclonal IgG1 antibody that specifically detects HPV16 L2 in HPV 16 through western blotting (WB) and immunofluorescence (IF). HPV16 L2 monoclonal antibody (2JGmab#4) recognizes a protein crucial in the human papillomavirus life cycle, particularly during viral genome assembly and encapsidation. HPV16 L2 (2JGmab#4) antibody targets a nuclear protein that interacts with the major capsid protein L1, enabling viral capsid formation. This interaction facilitates viral DNA packaging, as the C-terminus of L2 binds to L1 before capsid assembly. HPV16 L2 (2JGmab#4) monoclonal antibody helps researchers understand protein localization and function, which is essential for developing therapeutic interventions against HPV-related diseases, including cervical cancer. Anti-HPV16 L2 antibody (2JGmab#4) serves as a valuable research tool for studying HPV infection mechanisms and developing neutralizing antibodies against this oncogenic virus.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HPV16 L2 Antibody (2JGmab#4) References:
- Nuclear translocation of papillomavirus minor capsid protein L2 requires Hsc70. | Florin, L., et al. 2004. J Virol. 78: 5546-53. PMID: 15140951
- The minor capsid protein L2 contributes to two steps in the human papillomavirus type 31 life cycle. | Holmgren, SC., et al. 2005. J Virol. 79: 3938-48. PMID: 15767396
- Human papillomavirus 16 minor capsid protein L2 helps capsomeres assemble independently of intercapsomeric disulfide bonding. | Ishii, Y., et al. 2005. Virus Genes. 31: 321-8. PMID: 16175337
- Nuclear location of minor capsid protein L2 is required for expression of a reporter plasmid packaged in HPV51 pseudovirions. | Kondo, K., et al. 2009. Virology. 394: 259-65. PMID: 19766281
- The nuclear retention signal of HPV16 L2 protein is essential for incoming viral genome to transverse the trans-Golgi network. | DiGiuseppe, S., et al. 2014. Virology. 458-459: 93-105. PMID: 24928042
- Direct binding of retromer to human papillomavirus type 16 minor capsid protein L2 mediates endosome exit during viral infection. | Popa, A., et al. 2015. PLoS Pathog. 11: e1004699. PMID: 25693203
- Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2. | Tumban, E., et al. 2015. Vaccine. 33: 3346-53. PMID: 26003490
- Cleavage of the HPV16 Minor Capsid Protein L2 during Virion Morphogenesis Ablates the Requirement for Cellular Furin during De Novo Infection. | Cruz, L., et al. 2015. Viruses. 7: 5813-30. PMID: 26569287
- Subcellular Trafficking of the Papillomavirus Genome during Initial Infection: The Remarkable Abilities of Minor Capsid Protein L2. | Campos, SK. 2017. Viruses. 9: PMID: 29207511
- Refolding and in vitro characterization of human papillomavirus 16 minor capsid protein L2. | Breiner, B., et al. 2019. Biol Chem. 400: 513-522. PMID: 30375341
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HPV16 L2 Antibody (2JGmab#4) | sc-65708 | 200 µg/ml | $316.00 |