Date published: 2025-11-22

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HoxA1 Antibody (1E10): sc-293257

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Datasheets
  • HoxA1 Antibody (1E10) is a mouse monoclonal IgG3 κ HoxA1 antibody, cited in 3 publications, provided at 100 µg/ml
  • raised against a partial recombinant protein mapping within amino acids 11-119 of HoxA1 of human origin
  • recommended for detection of HoxA1 of human origin by WB, IP and ELISA
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HoxA1 Antibody (1E10). This work is in progress.

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HoxA1 Antibody (1E10) is a mouse monoclonal IgG3 kappa light chain antibody that detects HoxA1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-HoxA1 antibody (1E10) is available as the non-conjugated format. HoxA1 (1E10) antibody recognizes a crucial transcription factor that plays a significant role in the regulation of gene expression during embryonic development, particularly in the formation of the vertebrate central nervous system, heart, and limbs. HoxA1 (1E10) monoclonal antibody targets a protein vital for normal embryogenesis, as HoxA1 helps orchestrate the complex processes of cell differentiation and organogenesis. Notably, retinoic acid regulates HoxA1 expression and activity, highlighting the importance of external signaling in developmental processes. Aberrant expression of HoxA1 has been implicated in various cancers, including mammary tumors, where HoxA1 is not found in normal or precancerous tissues, suggesting potential use as a biomarker for tumorigenesis. HoxA1′s ability to interact with other proteins in the regulatory network further emphasizes its importance in developmental biology and cancer research, making anti-HoxA1 antibody (1E10) an essential tool for scientists studying these critical processes.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

HoxA1 Antibody (1E10) References:

  1. Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord.  |  Hao, Z., et al. 1999. Dev Dyn. 216: 201-17. PMID: 10536059
  2. Temporal and spatial expression of Hoxa-2 during murine palatogenesis.  |  Nazarali, A., et al. 2000. Cell Mol Neurobiol. 20: 269-90. PMID: 10789828
  3. Sequence analysis and tissue specific expression of human HOXA7.  |  Kim, MH., et al. 2000. Mol Biotechnol. 14: 19-24. PMID: 10911612
  4. Molecular cloning and analysis of a group of genes differentially expressed in cells which overexpress the Hoxa-1 homeobox gene.  |  Shen, J., et al. 2000. Exp Cell Res. 259: 274-83. PMID: 10942599
  5. Human HOX gene mutations.  |  Goodman, FR. and Scambler, PJ. 2001. Clin Genet. 59: 1-11. PMID: 11206481
  6. Elevated HOXA1 expression correlates with accelerated tumor cell proliferation and poor prognosis in gastric cancer partly via cyclin D1.  |  Yuan, C., et al. 2016. J Exp Clin Cancer Res. 35: 15. PMID: 26791264
  7. HOXA1 Is an Antagonist of ERα in Breast Cancer.  |  Belpaire, M., et al. 2021. Front Oncol. 11: 609521. PMID: 34490074
  8. HOXA1 promotes aerobic glycolysis and cancer progression in cervical cancer.  |  Zhang, Z., et al. 2023. Cell Signal. 109: 110747. PMID: 37286120
  9. HOXA1 participates in VSMC-to-macrophage-like cell transformation via regulation of NF-κB p65 and KLF4: a potential mechanism of atherosclerosis pathogenesis.  |  Han, Z., et al. 2023. Mol Med. 29: 104. PMID: 37528397
  10. Role of HOXA1-4 in the development of genetic and malignant diseases.  |  Wang, L., et al. 2024. Biomark Res. 12: 18. PMID: 38311789
  11. Repression by HoxA7 is mediated by the homeodomain and the modulatory action of its N-terminal-arm residues.  |  Schnabel, CA. and Abate-Shen, C. 1996. Mol Cell Biol. 16: 2678-88. PMID: 8649375
  12. Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells.  |  Srebrow, A., et al. 1998. J Cell Biochem. 69: 377-91. PMID: 9620166

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

HoxA1 Antibody (1E10)

sc-293257
100 µg/ml
$316.00

For Western Blot, is it recommended to use denatured or non-denatured conditions with HoxA1 (1E10): sc-293257 antibody?

Asked by: cjMara
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
Answered by: Technical Support
Date published: 2017-03-27
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Rated 5 out of 5 by from Good for multiple applicationsAntibody has been used to detect HoxA1 by Chromatin Immunoprecipitation and Western Blot in published research. -SCBT QC
Date published: 2023-09-14
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HoxA1 Antibody (1E10) is rated 5.0 out of 5 by 1.
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