Molecular structure of HNE-DMA
HNE-DMA
Molecular Weight:
202.29
Molecular Formula:
C11H22O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
HNE-DMA is a stable form of HNE and a toxic second messenger of free radicals. 4-Hydroxynonenal (HNE) is a highly reactive compound formed as a byproduct during lipid peroxidation. It plays a role in various cellular processes, especially in the context of oxidative stress, and has been implicated in a variety of pathological conditions due to its cytotoxicity. The dimethylacetal (DMA) form, HNE-DMA, is a stabilized version of HNE that can be used in research to study the effects of HNE without the rapid degradation typically seen with the parent compound.
HNE-DMA References
- 4-hydroxynonenal prevents NO production in vascular smooth muscle cells by inhibiting nuclear factor-kappaB-dependent transcriptional activation of inducible NO synthase. | Hattori, Y., et al. 2001. Arterioscler Thromb Vasc Biol. 21: 1179-83. PMID: 11451748
- Distinct involvement of NF-kappaB and p38 mitogen-activated protein kinase pathways in serum deprivation-mediated stimulation of inducible nitric oxide synthase and its inhibition by 4-hydroxynonenal. | Liu, W., et al. J Cell Biochem. 83: 271-80. PMID: 11573244
- Carbonyl toxicology and Alzheimer's disease. | Picklo, MJ., et al. 2002. Toxicol Appl Pharmacol. 184: 187-97. PMID: 12460747
- Synthesis and characterization of 4-hydroxy-2-nonenal derivatives for gas chromatographic analysis with electron capture detection (GC-ECD). | Santaniello, E., et al. 2007. Redox Rep. 12: 55-8. PMID: 17263910
- Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. | Wei, H., et al. 2009. Anesthesiology. 111: 147-54. PMID: 19512877
- Induction of CMV-1 promoter by 4-hydroxy-2-nonenal in human embryonic kidney cells. | Jaganjac, M., et al. 2010. Acta Biochim Pol. 57: 179-83. PMID: 20512167
- Synthesis, physicochemical characterization, and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents. | Bertinaria, M., et al. 2011. J Med Chem. 54: 611-21. PMID: 21182325
- Inhibition of ROS production through mitochondria-targeted antioxidant and mitochondrial uncoupling increases post-thaw sperm viability in yellow catfish. | Fang, L., et al. 2014. Cryobiology. 69: 386-93. PMID: 25260932
- A comparison of CRISPR/Cas9 and siRNA-mediated ALDH2 gene silencing in human cell lines. | Wang, F., et al. 2018. Mol Genet Genomics. 293: 769-783. PMID: 29383448
- The Role of Acrolein and NADPH Oxidase in the Granulocyte-Mediated Growth-Inhibition of Tumor Cells. | Jaganjac, M., et al. 2019. Cells. 8: PMID: 30934946
- A validated UHPLC-MS/MS method for simultaneous quantification of 9 exocyclic DNA adducts induced by 8 aldehydes. | Alamil, H., et al. 2020. J Pharm Biomed Anal. 179: 113007. PMID: 31796220
- In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism. | Petkovic, I., et al. 2020. Antioxidants (Basel). 9: PMID: 32053996
- Genotoxicity of aldehyde mixtures: profile of exocyclic DNA-adducts as a biomarker of exposure to tobacco smoke. | Alamil, H., et al. 2020. Toxicol Lett. 331: 57-64. PMID: 32442718
- Lipid Peroxidation Products HNE and ONE Promote and Stabilize Alpha-Synuclein Oligomers by Chemical Modifications. | Andersen, C., et al. 2021. Biochemistry. 60: 3644-3658. PMID: 34730940
- Reaction of 4-hydroxynonenal with some thiol-containing radioprotective agents or their active metabolites. | de Toranzo, EG. and Castro, JA. 1994. Free Radic Biol Med. 17: 605-7. PMID: 7867976
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HNE-DMA, 2 mg | sc-300801 | 2 mg | $117.00 |