HC Toxin (CAS 83209-65-8)
See product citations (1)
QUICK LINKS
HC Toxin, a naturally occurring compound present in various plant species, emerges as a small, lipophilic molecule that manifests under conditions of environmental stress. This intriguing substance serves as a defense mechanism within plants. Simultaneously, its potential as an insecticide has been investigated, proving effective against a wide array of insect pests. Although the precise mechanism of action for HC Toxin remains incompletely understood, it is believed to operate by inhibiting the activity of enzymes in lipid, protein, and carbohydrate metabolism. Furthermore, HC Toxin demonstrates the ability to hinder the growth of bacteria, fungi, and viruses, potentially achieved through disruption of their cell walls.
HC Toxin (CAS 83209-65-8) References
- The cyclic peptide synthetase catalyzing HC-toxin production in the filamentous fungus Cochliobolus carbonum is encoded by a 15.7-kilobase open reading frame. | Scott-Craig, JS., et al. 1992. J Biol Chem. 267: 26044-9. PMID: 1281482
- Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. | Joung, KE., et al. 2004. Arch Pharm Res. 27: 640-5. PMID: 15283467
- Enzymatic Detoxification of HC-toxin, the Host-Selective Cyclic Peptide from Cochliobolus carbonum. | Meeley, RB. and Walton, JD. 1991. Plant Physiol. 97: 1080-6. PMID: 16668492
- HC-toxin. | Walton, JD. 2006. Phytochemistry. 67: 1406-13. PMID: 16839576
- Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells. | Deubzer, HE., et al. 2008. Int J Cancer. 122: 1891-900. PMID: 18074352
- Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro. | Deubzer, HE., et al. 2008. Cancer Lett. 264: 21-8. PMID: 18262346
- Conservation of the genes for HC-toxin biosynthesis in Alternaria jesenskae. | Wight, WD., et al. 2013. BMC Microbiol. 13: 165. PMID: 23865912
- HC toxin (a HDAC inhibitor) enhances IRS1-Akt signalling and metabolism in mouse myotubes. | Tan, HW., et al. 2015. J Mol Endocrinol. 55: 197-207. PMID: 26373795
- Histone deacetylase inhibitor screening identifies HC toxin as the most effective in intrahepatic cholangiocarcinoma cells. | Zhou, W., et al. 2016. Oncol Rep. 35: 2535-42. PMID: 26935789
- Reciprocal biological activities of the cyclic tetrapeptides chlamydocin and HC-toxin. | Walton, JD., et al. 1985. Experientia. 41: 348-50. PMID: 3918884
- Inhibition of maize histone deacetylases by HC toxin, the host-selective toxin of Cochliobolus carbonum. | Brosch, G., et al. 1995. Plant Cell. 7: 1941-50. PMID: 8535144
- Comments on the article 'Persistent confusion of total entropy and chemical system entropy in chemical thermodynamics' [(1996) Proc. Natl. Acad. Sci. USA 93, 7452-7453]. | Ross, J. 1996. Proc Natl Acad Sci U S A. 93: 14314; discussion 14315. PMID: 8962046
- Induction of gamma-globin by histone deacetylase inhibitors. | McCaffrey, PG., et al. 1997. Blood. 90: 2075-83. PMID: 9292546
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HC Toxin, 1 mg | sc-200884 | 1 mg | $158.00 |