Harmane (CAS 486-84-0)
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Harmane is a putative endogenous imidazoline ligand for imidazoline binding sites. Harmane binds to I1-sites in rat kidney with an IC50 of 31 nM, and I2-sites with a Ki of 49 nM. Harmane is also a potent inhibitor of monoamine oxidases A and B (IC50 values are 0.5 and 5 muM respectively). Harmane is an analytical reference standard categorized as a β-carboline alkaloid. Harmane has been found in Psilocybe mushrooms. This product is intended for analytical forensic applications. This product is also available as a general research tool.Nanomolar affinity for the I1-imidazoline receptor (IC50 = 30 nM). Endogenous to the brain. Able to cross the blood-brain barrier. Active at I1, I2 and I3 binding sites, 1000-fold selectivity for I1 over α2 adrenoceptors.
Harmane (CAS 486-84-0) References
- Toxicokinetics of tremorogenic natural products, harmane and harmine, in male Sprague-Dawley rats. | Guan, Y., et al. 2001. J Toxicol Environ Health A. 64: 645-60. PMID: 11766171
- Harmane inhibits serotonergic dorsal raphe neurons in the rat. | Touiki, K., et al. 2005. Psychopharmacology (Berl). 182: 562-9. PMID: 16133137
- Electrophysiological characterization of harmane-induced activation of mesolimbic dopamine neurons. | Arib, O., et al. 2010. Eur J Pharmacol. 629: 47-52. PMID: 20026027
- Blood harmane, blood lead, and severity of hand tremor: evidence of additive effects. | Louis, ED., et al. 2011. Neurotoxicology. 32: 227-32. PMID: 21145352
- The modulatory action of harmane on serotonergic neurotransmission in rat brain. | Abu Ghazaleh, H., et al. 2015. Brain Res. 1597: 57-64. PMID: 25498864
- Harmane: an atypical neurotransmitter? | Abu Ghazaleh, H., et al. 2015. Neurosci Lett. 590: 1-5. PMID: 25625221
- Pharmacokinetic study of harmane and its 10 metabolites in rat after intravenous and oral administration by UPLC-ESI-MS/MS. | Li, S., et al. 2016. Pharm Biol. 54: 1768-81. PMID: 26730489
- Pharmacological and Toxicological Profile of Harmane-β-Carboline Alkaloid: Friend or Foe. | Khan, H., et al. 2017. Curr Drug Metab. 18: 853-857. PMID: 28595532
- From the Cover: Harmane-Induced Selective Dopaminergic Neurotoxicity in Caenorhabditis elegans. | Sammi, SR., et al. 2018. Toxicol Sci. 161: 335-348. PMID: 29069497
- Abolishment of fear memory-disruptive effects REM sleep deprivation by harmane. | Nasehi, M., et al. 2019. Biomed Pharmacother. 109: 1563-1568. PMID: 30551409
- Blood Harmane (1-Methyl-9H-Pyrido[3,4-b]indole) and Mercury in Essential Tremor: A Population-Based, Environmental Epidemiology Study in the Faroe Islands. | Louis, ED., et al. 2020. Neuroepidemiology. 54: 272-280. PMID: 32007995
- Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning. | Li, Y., et al. 2020. RSC Adv. 10: 4397-4403. PMID: 35495252
- Lipid class-dependent alterations of Caenorhabditis elegans under harmane exposure. | Nguyen, BT., et al. 2023. J Pharm Biomed Anal. 231: 115401. PMID: 37105045
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Harmane, 10 mg | sc-203594B | 10 mg | $44.00 | |||
Harmane, 10 mg | sc-203594B-CW | 10 mg | $49.00 | |||
Harmane, 100 mg | sc-203594 | 100 mg | $77.00 | |||
Harmane, 1 g | sc-203594A | 1 g | $246.00 |