Molecular structure of GSK-J5 Hydrochloride
GSK-J5 Hydrochloride (CAS 1394854-51-3 (free base))
Application:
GSK-J5 Hydrochloride is a pyridine regio-isomer of GSK-J4. GSK-J4 that is also cell-permeable and hydrolyzed to a free base
CAS Number:
1394854-51-3 (free base)
Molecular Weight:
453.96
Molecular Formula:
C24H27N5O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
GSK-J5 is a pyridine regio-isomer of GSK-J4. GSK-J4 is a cell-permeable prodrug which is modified by intracellular esterases to give GSK-J1, an inhibitor of JMJD3. The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. Like GSK-J4, GSK-J5 is cell-permeable and hydrolyzed to a free base. However, the free base is a weak inhibitor of JMJD3 (IC50 > 100 μM), making it an ideal inactive control molecule for elucidating the functional role of JMJD3 inhibition.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-J5 Hydrochloride, 5 mg | sc-490342 | 5 mg | $300.00 |