Molecular structure of GSK-3 Inhibitor XIII, CAS Number: 404828-08-6
GSK-3 Inhibitor XIII (CAS 404828-08-6)
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Alternate Names:
(5-Methyl-1H-pyrazol-3-yl)-(2-phenylquinazolin-4-yl)amine
Application:
GSK-3 Inhibitor XIII is an ATP-binding site inhibitor of GSK-3
CAS Number:
404828-08-6
Purity:
≥95%
Molecular Weight:
301.4
Molecular Formula:
C18H15N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
GSK-3 Inhibitor XIII is an aminopyrazole compound that acts as an ATP-binding site inhibitor of GSK-3. Studies suggest that GSK-3 is a multifunctional serine/threonine kinase involved in estrogen and androgen receptor stability by phosphorylation. GSK-3 can bind to androgen receptors forming complexes in the cytoplasm and nucleus, so inhibition by GSK-3 Inhibitor XIII, will result in a rapid nuclear export of endogenous androgen receptors thus reducing receptors for the enzyme to bind to.
GSK-3 Inhibitor XIII (CAS 404828-08-6) References
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- Inhibition of glycogen synthase kinase-3 in androgen-responsive prostate cancer cell lines: are GSK inhibitors therapeutically useful? | Rinnab, L., et al. 2008. Neoplasia. 10: 624-34. PMID: 18516299
- IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. | Han, D., et al. 2009. Cell. 138: 562-75. PMID: 19665977
- Inhibition of glycogen synthase kinase-3beta promotes nuclear export of the androgen receptor through a CRM1-dependent mechanism in prostate cancer cell lines. | Schütz, SV., et al. 2010. J Cell Biochem. 109: 1192-200. PMID: 20127713
- Estrogen receptor beta signaling through phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt/glycogen synthase kinase 3 down-regulates blood-brain barrier breast cancer resistance protein. | Hartz, AM., et al. 2010. J Pharmacol Exp Ther. 334: 467-76. PMID: 20460386
- A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS. | Yang, YM., et al. 2013. Cell Stem Cell. 12: 713-26. PMID: 23602540
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- High-throughput screening and bioinformatic analysis to ascertain compounds that prevent saturated fatty acid-induced β-cell apoptosis. | Lee, SH., et al. 2017. Biochem Pharmacol. 138: 140-149. PMID: 28522407
- Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase. | Marina Perez, A., et al. 2017. BMC Biochem. 18: 12. PMID: 28724347
- Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. | Arnold, FJ., et al. 2019. Sci Rep. 9: 119. PMID: 30644418
- Non-linear Deep Neural Network for Rapid and Accurate Prediction of Phenotypic Responses to Kinase Inhibitors. | Vijay, S. and Gujral, TS. 2020. iScience. 23: 101129. PMID: 32434142
- High Throughput Fluorescence-Based In Vitro Experimental Platform for the Identification of Effective Therapies to Overcome Tumour Microenvironment-Mediated Drug Resistance in AML. | Arroyo-Berdugo, Y., et al. 2023. Cancers (Basel). 15: PMID: 37046649
Inhibitor of:
GSK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-3 Inhibitor XIII, 1 mg | sc-203987 | 1 mg | $164.00 | |||
GSK-3 Inhibitor XIII, 5 mg | sc-203987A | 5 mg | $480.00 |