GM1 Pentasaccharide sodium salt (CAS 67063-78-9)
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GM1 Pentasaccharide sodium salt is a derivative of GM1 ganglioside, consisting of the oligosaccharide portion of the molecule. This compound is primarily used in studies focusing on carbohydrate-protein interactions, specifically the binding of bacterial toxins and other protein ligands to cell surface carbohydrates. In research, GM1 Pentasaccharide sodium salt serves as a simplified model to understand how the full-length GM1 ganglioside functions in cellular recognition and signal transduction processes. It is also a tool for investigating the mechanisms of microbial pathogenesis, as certain bacteria and viruses utilize the carbohydrate structures on cell membranes to attach and initiate infection. Additionally, this compound is employed in the development of assays to study the specificity and affinity of carbohydrate-binding proteins, which can provide insights into the development of inhibitors that can block these interactions.
GM1 Pentasaccharide sodium salt (CAS 67063-78-9) References
- Interferon-gamma: an overview of signals, mechanisms and functions. | Schroder, K., et al. 2004. J Leukoc Biol. 75: 163-89. PMID: 14525967
- T cells from patients with Guillain-Barré syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1. | McCombe, PA. and Csurhes, PA. 2010. J Clin Neurosci. 17: 537-8. PMID: 20093028
- Bis(monoacylglycero)phosphate and ganglioside GM1 spontaneously form small homogeneous vesicles at specific concentrations. | Chebukati, JN., et al. 2010. Biochem Biophys Res Commun. 394: 509-14. PMID: 20206128
- Interactive configuration through force analysis of GM1 pentasaccharide-Vibrio cholera toxin interaction. | Seo, JH., et al. 2011. Anal Chem. 83: 6011-7. PMID: 21699239
- Binding of Vibrio cholera toxin and the heat-labile enterotoxin of Escherichia coli to GM1, derivatives of GM1, and nonlipid oligosaccharide polyvalent ligands. | Schengrund, CL. and Ringler, NJ. 1989. J Biol Chem. 264: 13233-7. PMID: 2666416
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GM1 Pentasaccharide sodium salt, 1 mg | sc-203060 | 1 mg | $475.00 |