Date published: 2026-3-20

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Geodin (CAS 427-63-4)

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Alternate Names:
Estin
Application:
Geodin is an inhibitor of plasminogen activator inhibitor (PAI-1)
CAS Number:
427-63-4
Purity:
≥95%
Molecular Weight:
399.18
Molecular Formula:
C17H12Cl2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Geodin is a chemical that functions as an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase. It acts by binding to the active site of the enzyme, preventing the conversion of HMG-CoA to mevalonate, a key step in the biosynthesis of cholesterol. This inhibition leads to a decrease in the production of cholesterol in cells. Geodin′s mechanism of action involves disrupting the normal enzymatic activity of HMG-CoA reductase, thereby interfering with the cellular processes involved in cholesterol synthesis. By targeting this specific enzyme, Geodin has the ability to modulate cholesterol levels within experimental systems, providing insights into the regulation of cholesterol biosynthesis and potential implications for cellular function.


Geodin (CAS 427-63-4) References

  1. Enhancement of fibrinolytic activity of vascular endothelial cells by chaetoglobosin A, crinipellin B, geodin and triticone B.  |  Shinohara, C., et al. 2000. J Antibiot (Tokyo). 53: 262-8. PMID: 10819297
  2. Preparation and characterization of geodin. A betagamma-crystallin-type protein from a sponge.  |  Giancola, C., et al. 2005. FEBS J. 272: 1023-35. PMID: 15691335
  3. Studies in the biochemistry of micro-organisms: Itaconic acid, a metabolic product of a strain of Aspergillus terreus Thom.  |  Calam, CT., et al. 1939. Biochem J. 33: 1488-95. PMID: 16747058
  4. Studies in the biochemistry of micro-organisms: (A) A survey of chlorine metabolism by moulds. (B) Caldariomycin, C(5)H(8)O(2)Cl(2), a metabolic product of Caldariomyces fumago Woronichin.  |  Clutterbuck, PW., et al. 1940. Biochem J. 34: 664-77. PMID: 16747206
  5. Sclerotiorine, C(20)H(20)O(5)Cl, a chlorine-containing metabolic product of Penicillium sclerotiorum van Beyma.  |  Curtin, TP. and Reilly, J. 1940. Biochem J. 34: 1418.1-1421. PMID: 16747272
  6. Studies on antibiotics: 2. Bacteriological activity and possible mode of action of certain non-nitrogenous natural and synthetic antibiotics.  |  Rinderknecht, H., et al. 1947. Biochem J. 41: 463-9. PMID: 16748192
  7. Aspergillus uvarum sp. nov., an uniseriate black Aspergillus species isolated from grapes in Europe.  |  Perrone, G., et al. 2008. Int J Syst Evol Microbiol. 58: 1032-9. PMID: 18398215
  8. Heterologous reconstitution of the intact geodin gene cluster in Aspergillus nidulans through a simple and versatile PCR based approach.  |  Nielsen, MT., et al. 2013. PLoS One. 8: e72871. PMID: 24009710
  9. Identification of the first diphenyl ether gene cluster for pestheic acid biosynthesis in plant endophyte Pestalotiopsis fici.  |  Xu, X., et al. 2014. Chembiochem. 15: 284-92. PMID: 24302702
  10. Redundant synthesis of a conidial polyketide by two distinct secondary metabolite clusters in Aspergillus fumigatus.  |  Throckmorton, K., et al. 2016. Environ Microbiol. 18: 246-59. PMID: 26242966
  11. Proteome Profile of Aspergillus terreus Conidia at Germinating Stage: Identification of Probable Virulent Factors and Enzymes from Mycotoxin Pathways.  |  Thakur, R. and Shankar, J. 2017. Mycopathologia. 182: 771-784. PMID: 28647921
  12. Classic fungal natural products in the genomic age: the molecular legacy of Harold Raistrick.  |  Schor, R. and Cox, R. 2018. Nat Prod Rep. 35: 230-256. PMID: 29537034
  13. Characterization and Structural Analysis of Emodin-O-Methyltransferase from Aspergillus terreus.  |  Xue, Y., et al. 2022. J Agric Food Chem. 70: 5728-5737. PMID: 35475366

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Geodin, 1 mg

sc-280731
1 mg
$124.00

Geodin, 5 mg

sc-280731A
5 mg
$500.00