GDE1 Antibody (202B2X): sc-517642

GDE1 Antibody (202B2X) is a mouse monoclonal IgG1 kappa light chain antibody that detects GDE1 protein of human origin by western blotting (WB). Anti-GDE1 antibody (202B2X) is available as a non-conjugated format. GDE1, also known as glycerophosphodiester phosphodiesterase 1 or MIR16, is a 331 amino acid multi-pass membrane protein primarily localized to the membrane and cytoplasm, featuring a single GDPD domain. GDE1 plays a crucial role in cellular signaling by utilizing magnesium as a cofactor to catalyze the conversion of 1-(sn-glycero-3-phospho)-1D-myo-inositol into myo-inositol and sn-glycerol 3-phosphate. This enzymatic activity is modulated by G protein signaling pathways, establishing a vital link between phosphoinositide metabolism and G protein signal transduction, which is essential for various physiological processes. The gene encoding GDE1 is located on human chromosome 16, a region that harbors over 900 genes and constitutes nearly 3% of the human genome. Mutations in genes on this chromosome, such as the GAN gene, can lead to serious conditions like giant axonal neuropathy, while other disorders like Rubinstein-Taybi syndrome and Crohn′s disease are also associated with this chromosomal region.

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GDE1 Antibody (202B2X) References:

1. MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16.  |  Zheng, B., et al. 2000. Proc Natl Acad Sci U S A. 97: 3999-4004. PMID: 10760272
2. GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors.  |  Zheng, B., et al. 2003. Proc Natl Acad Sci U S A. 100: 1745-50. PMID: 12576545
3. Glycerophosphocholine-dependent growth requires Gde1p (YPL110c) and Git1p in Saccharomyces cerevisiae.  |  Fisher, E., et al. 2005. J Biol Chem. 280: 36110-7. PMID: 16141200
4. Genomic organization, characterization, and molecular 3D model of GDE1, a novel mammalian glycerophosphoinositol phosphodiesterase.  |  Bachmann, AS., et al. 2006. Gene. 371: 144-53. PMID: 16472945
5. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.  |  Ma, J., et al. 2007. Atherosclerosis. 191: 63-72. PMID: 16806233
6. Mammalian glycerophosphodiester phosphodiesterases.  |  Yanaka, N. 2007. Biosci Biotechnol Biochem. 71: 1811-8. PMID: 17690467
7. Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain.  |  Simon, GM. and Cravatt, BF. 2008. J Biol Chem. 283: 9341-9. PMID: 18227059
8. The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice.  |  Kopp, F., et al. 2010. Chem Biol. 17: 831-40. PMID: 20797612
9. The genetic architecture of NAFLD among inbred strains of mice.  |  Hui, ST., et al. 2015. Elife. 4: e05607. PMID: 26067236
10. Mammalian enzymes responsible for the biosynthesis of N-acylethanolamines.  |  Hussain, Z., et al. 2017. Biochim Biophys Acta Mol Cell Biol Lipids. 1862: 1546-1561. PMID: 28843504
11. Glycerophosphodiester phosphodiesterase 1 (GDE1) acts as a potential tumor suppressor and is a novel therapeutic target for non-mucin-producing colon adenocarcinoma.  |  Shen, Q., et al. 2020. PeerJ. 8: e8421. PMID: 32095326
12. In vivo detection of dysregulated choline metabolism in paclitaxel-resistant ovarian cancers with proton magnetic resonance spectroscopy.  |  Lu, J., et al. 2022. J Transl Med. 20: 92. PMID: 35168606