GAPDH-2 Antibody (Hs-8): sc-51631

GAPDH-2 Antibody (Hs-8) is a mouse monoclonal IgM antibody that detects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in human and porcine samples through applications such as western blotting (WB) and immunofluorescence (IF). GAPDH is a crucial enzyme in the glycolytic pathway, catalyzing the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate, which is essential for energy production in carbohydrate metabolism. Beyond a well-established role in glycolysis, GAPDH is also involved in various cellular processes, including acting as a uracil DNA glycosylase, which is vital for DNA repair mechanisms, and participating in transcriptional regulation and RNA binding. Notably, GAPDH′s ability to translocate to the nucleus during apoptosis highlights GAPDH′s importance in programmed cell death, a critical process in maintaining cellular homeostasis. Furthermore, GAPDH interacts with several neuronal proteins associated with neurodegenerative disorders, such as the β-Amyloid precursor and Huntingtin, underscoring GAPDH′s potential role in the pathology of these diseases. GAPDH expression is often upregulated in various cancers, including liver, lung, and prostate cancers, making GAPDH a significant marker for cancer research. With multifaceted functions and implications in both metabolism and disease, anti-GAPDH antibody (Hs-8) serves as a valuable tool for researchers investigating the complexities of cellular processes and disease mechanisms.

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GAPDH-2 Antibody (Hs-8) References:

1. Increased mRNA expression of tumour necrosis factor-alpha and its converting enzyme in circulating leucocytes of patients with acute myocardial infarction.  |  Akatsu, T., et al. 2003. Clin Sci (Lond). 105: 39-44. PMID: 12605594
2. Experimental immunological infertility effect of anti-GAPDH-2 antibodies on the fertility of female mice.  |  Wang, Y., et al. 2009. Fertil Steril. 92: 2020-7. PMID: 18980760
3. Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death.  |  Nakajima, H., et al. 2009. J Biol Chem. 284: 34331-41. PMID: 19837666
4. Human antimicrobial peptides and proteins.  |  Wang, G. 2014. Pharmaceuticals (Basel). 7: 545-94. PMID: 24828484
5. [Large tumor suppressor gene 2-mediated Hippo signaling pathway regulates the biological behavior of mesenchymal stem cells in vitro].  |  Dong, L. and Li, L. 2019. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 31: 1143-1148. PMID: 31657341
6. [Protective effects of cordycepin on renal proximal tubular cells injury induced by lipopolysaccharide].  |  Yang, Y., et al. 2021. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 33: 203-206. PMID: 33729140
7. [Protective effect of forsythiaside A on acute lung injury in septic rats].  |  Cai, L. and Jiang, R. 2022. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 34: 710-713. PMID: 36100408
8. [Effects of tropomyosin 3 on pyroptosis of cardiomyocytes and fibroblast activation induced by hypoxia/reoxygenation in rats].  |  Tian, H. and Hu, H. 2023. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 35: 93-98. PMID: 36880246
9. [Mechanism of Notch3 signaling pathway regulating the differentiation of aortic dissection vascular stem cells into smooth muscle cells].  |  Han, Y., et al. 2023. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 35: 503-508. PMID: 37308231
10. Histone-Lysine N-Methyltransferase 2D (KMT2D) Impending Therapeutic Target for the Management of Cancer: The Giant Rats Tail.  |  Jasmin, MDC., et al. 2025. J Environ Pathol Toxicol Oncol. 44: 31-36. PMID: 39462447

The preferred Intra-acrosomal protein antibody is Intra-acrosomal protein Antibody (Ds-2): sc-51659.