Molecular structure of Ganglioside GD1b disodium salt, CAS Number: 19553-76-5
Ganglioside GD1b disodium salt (CAS 19553-76-5)
See product citations (6)
Alternate Names:
Disialoganglioside GD1b . 2Na; GD1b . 2Na
Application:
Ganglioside GD1b disodium salt is a ganglioside
CAS Number:
19553-76-5
Purity:
>98%
Molecular Weight:
1882.1 (Calculated based on sphingosine C18:1 and stearic acid)
Molecular Formula:
C84H146N4O39•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ganglioside GD1b disodium salt may act as a bacterial toxin receptor (tetanus, botulinus) high levels are found in gliomas and astrocytomas. Gangliosides are major constituents of neuronal cell membranes and endoplasmic reticulum and have been shown to modulate cell signal transduction. Gangliosides are more complex glycosphingolipids because oligosaccharide chains which have N-acetylneuraminic acid (NeuNAc) are attached to a ceramide.
Ganglioside GD1b disodium salt (CAS 19553-76-5) References
- Immunostaining of ganglioside GD1b, GD3 and GM1 in rat cerebellum: cellular layer and cell type specific associations. | Molander, M., et al. 2000. J Neurosci Res. 60: 531-42. PMID: 10797556
- Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells. | Kanda, N. and Watanabe, S. 2001. J Immunol. 166: 72-80. PMID: 11123278
- Ganglioside GD1b is the target antigen for a biclonal IgM in a case of sensory-motor axonal polyneuropathy: involvement of N-acetylneuraminic acid in the epitope. | Younes-Chennoufi, AB., et al. 1992. Ann Neurol. 32: 18-23. PMID: 1379422
- Alterations in neuroblastoma ganglioside synthesis by induction of GD1b synthase by retinoic acid. | Hettmer, S., et al. 2004. Br J Cancer. 91: 389-97. PMID: 15187999
- Calmodulin, a ganglioside-binding protein. Binding of gangliosides to calmodulin in the presence of calcium. | Higashi, H., et al. 1992. J Biol Chem. 267: 9831-8. PMID: 1577817
- Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins. | Mocchetti, I. 2005. Cell Mol Life Sci. 62: 2283-94. PMID: 16158191
- Inhibitory effect of ganglioside GD1b on K+ current in hippocampal neurons and its involvement in apoptosis suppression. | Chen, X., et al. 2005. J Lipid Res. 46: 2580-5. PMID: 16199892
- Identification of gangliosides GD1b and GT1b as receptors for BK virus. | Low, JA., et al. 2006. J Virol. 80: 1361-6. PMID: 16415013
- The alpha-galactosyl derivatives of ganglioside GD(1b) are essential for the organization of lipid rafts in RBL-2H3 mast cells. | Silveira e Souza, AM., et al. 2008. Exp Cell Res. 314: 2515-28. PMID: 18585706
- Exogenous gangliosides GD1b and GD1b-lactone, stably associated to rat brain P2 subcellular fraction, modulate differently the process of protein phosphorylation. | Bassi, R., et al. 1991. J Neurochem. 57: 1207-11. PMID: 1895103
- Differential distribution of major brain gangliosides in the adult mouse central nervous system. | Vajn, K., et al. 2013. PLoS One. 8: e75720. PMID: 24098718
- Monoclonal antibody AA4, which inhibits binding of IgE to high affinity receptors on rat basophilic leukemia cells, binds to novel alpha-galactosyl derivatives of ganglioside GD1b. | Guo, NH., et al. 1989. J Biol Chem. 264: 13267-72. PMID: 2526814
- Exogenous and Endogeneous Disialosyl Ganglioside GD1b Induces Apoptosis of MCF-7 Human Breast Cancer Cells. | Ha, SH., et al. 2016. Int J Mol Sci. 17: PMID: 27144558
- Natural occurrence of ganglioside lactones. Isolation and characterization of GD1b inner ester from adult human brain. | Riboni, L., et al. 1986. J Biol Chem. 261: 8514-9. PMID: 3722160
- A monoclonal antibody that recognizes ganglioside GD1b in the rat central nervous system. | Maehara, T., et al. 1997. Neurosci Res. 29: 9-16. PMID: 9293488
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ganglioside GD1b disodium salt, 1 mg | sc-202622 | 1 mg | $281.00 |