FUSIP1 Antibody (T-18): sc-101132

FUSIP1 Antibody (T-18) is a mouse monoclonal IgG1 kappa light chain antibody that detects FUSIP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-FUSIP1 antibody (T-18) is available as a non-conjugated format. FUSIP1, also known as FUS interacting protein (serine/arginine-rich) 1, NSSR, TASR (TLS-associated protein with Ser-Arg repeats), SRp38, TASR1, TASR2, FUSIP2, SFRS13, or SRrp40, is a crucial member of the Serine/Arginine (SR) family of splicing factors, which are integral to the regulation of pre-mRNA splicing. FUSIP1 is characterized by the presence of one or more RNA recognition motifs and an SR-rich domain, allowing FUSIP1 to play a significant role in both constitutive and alternative splicing processes. FUSIP1 is predominantly expressed in various tissues, with lower levels found in the kidney, liver, and heart, and FUSIP1 is localized in the cytoplasm and nuclear speckles. Notably, FUSIP1 undergoes post-translational modifications, particularly phosphorylation, which alters FUSIP1 function; in its dephosphorylated state during the M phase of the cell cycle, FUSIP1 acts as a general repressor of pre-mRNA splicing, while phosphorylation enables FUSIP1 interaction with Tra-2β, suggesting a cooperative role in splicing regulation. The existence of four FUSIP1 isoforms adds complexity to FUSIP1 function, particularly in neurons, where these isoforms can differentially influence alternative splicing, highlighting FUSIP1′s importance in gene expression regulation and potential implications in various biological processes and diseases.

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FUSIP1 Antibody (T-18) References:

1. Cloning and characterization of two neural-salient serine/arginine-rich (NSSR) proteins involved in the regulation of alternative splicing in neurones.  |  Komatsu, M., et al. 1999. Genes Cells. 4: 593-606. PMID: 10583508
2. The SR protein SRp38 represses splicing in M phase cells.  |  Shin, C. and Manley, JL. 2002. Cell. 111: 407-17. PMID: 12419250
3. NSSR1 promotes neuronal differentiation of mouse embryonic carcinoma P19 cells.  |  Liu, L., et al. 2004. Neuroreport. 15: 823-8. PMID: 15073523
4. NSSRs/TASRs/SRp38s function as splicing modulators via binding to pre-mRNAs.  |  Fushimi, K., et al. 2005. Genes Cells. 10: 531-41. PMID: 15938712
5. TASR-1 regulates alternative splicing of collagen genes in chondrogenic cells.  |  Matsushita, H., et al. 2007. Biochem Biophys Res Commun. 356: 411-7. PMID: 17367759
6. NSSR1 is regulated in testes development and cryptorchidism and promotes the exon 5-included splicing of CREB transcripts.  |  Xiao, PJ., et al. 2007. Mol Reprod Dev. 74: 1363-72. PMID: 17427975
7. A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock.  |  Shi, Y. and Manley, JL. 2007. Mol Cell. 28: 79-90. PMID: 17936706
8. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing.  |  Yang, L., et al. 1998. J Biol Chem. 273: 27761-4. PMID: 9774382

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-FUSIP1 Antibody (T-18) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-FUSIP1 Antibody (T-18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

FUSIP1 Antibody (T-18) Specifications

Alternate Product Name: FUSIP1

Product Clone Name: T-18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-101

Epitope Target: FUSIP1

Epitope Species: human

Product Reactivity/Detection: FUSIP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for FUSIP1 Antibody (T-18): N/A