FTI-277 trifluoroacetate salt (CAS 170006-73-2 (free base))

FTI-277 trifluoroacetate salt is an inhibitor of farnesyl transferase (FTase). Studies show the compound to be a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. It is used in scientific research for its ability to inhibit the activity of farnesyltransferase, an enzyme involved in protein prenylation. FTI-277 trifluoroacetate salt is the trifluoroacetate salt form of the compound. As a potent FTI, FTI-277 trifluoroacetate salt exerts its inhibitory effects on farnesyltransferase by binding to the enzyme and preventing the transfer of a farnesyl group to target proteins. This inhibition disrupts the normal signaling pathways regulated by farnesylated proteins, which are involved in various cellular processes such as cell proliferation and survival. In scientific research, FTI-277 trifluoroacetate salt is widely utilized to study the role of farnesyltransferase and farnesylation in different biological systems. It has been employed to investigate the impact of farnesyltransferase inhibition on cancer cells, as certain proteins involved in tumor growth and metastasis require farnesylation for their proper function. By inhibiting farnesyltransferase, FTI-277 trifluoroacetate salt shows potential as an anticancer agent by interfering with the signaling pathways that drive tumor progression.