FTase Inhibitor II (CAS 156707-43-6)
QUICK LINKS
FTase Inhibitor II is a compound used in the study of protein prenylation, specifically focusing on the inhibition of farnesyltransferase, an enzyme responsible for the attachment of a farnesyl group to proteins. This modification is for the proper functioning and localization of various proteins within the cell, including members of the Ras superfamily. Inhibition of farnesyltransferase by FTase Inhibitor II is employed in research to understand the role of protein prenylation in cell signaling, cell cycle progression, and oncogenesis. It is particularly relevant in the study of cancer biology, as the farnesylation of oncogenic Ras proteins is a key step in their activation and in the development of malignancies. Additionally, FTase Inhibitor II is used to explore the potential of targeting farnesyltransferase in the design of new strategies for intervention in diseases characterized by aberrant protein prenylation.
FTase Inhibitor II (CAS 156707-43-6) References
- Eicosanoid activation of extracellular signal-regulated kinase1/2 in human epidermoid carcinoma cells. | Szekeres, CK., et al. 2000. J Biol Chem. 275: 38831-41. PMID: 10952974
- RAM2: an essential gene in the prenylation pathway of Candida albicans. | Song, JL. and White, TC. 2003. Microbiology (Reading). 149: 249-59. PMID: 12576598
- Positively charged side chains in protein farnesyltransferase enhance catalysis by stabilizing the formation of the diphosphate leaving group. | Bowers, KE. and Fierke, CA. 2004. Biochemistry. 43: 5256-65. PMID: 15122891
- The RAM1 gene encoding a protein-farnesyltransferase beta-subunit homologue is essential in Cryptococcus neoformans. | Vallim, MA., et al. 2004. Microbiology (Reading). 150: 1925-1935. PMID: 15184578
- Role of ERK in hydrogen peroxide-induced cell death of human glioma cells. | Lee, WC., et al. 2005. Neurochem Res. 30: 263-70. PMID: 15895830
- Farnesylthiosalicylic acid induces caspase activation and apoptosis in glioblastoma cells. | Amos, S., et al. 2006. Cell Death Differ. 13: 642-51. PMID: 16239932
- Stimulatory and suppressive signal transduction regulates vasoactive intestinal peptide receptor-1 (VPAC-1) in primary mouse CD4 T cells. | Vomhof-DeKrey, EE. and Dorsam, GP. 2008. Brain Behav Immun. 22: 1024-1031. PMID: 18555660
- Macrophage differentiation increases expression of the ascorbate transporter (SVCT2). | Qiao, H. and May, JM. 2009. Free Radic Biol Med. 46: 1221-32. PMID: 19232538
- Meroterpenoids and Chalcone-Lignoids from the Roots of Mimosa diplotricha. | Chiou, CT., et al. 2016. J Nat Prod. 79: 2439-2445. PMID: 27715048
- Efficient Inhibition of Human Papillomavirus Infection by L2 Minor Capsid-Derived Lipopeptide. | Yan, H., et al. 2019. mBio. 10: PMID: 31387913
- Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology. | Nazir, M., et al. 2021. Biomolecules. 11: PMID: 34209734
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FTase Inhibitor II, 1 mg | sc-221633 | 1 mg | $46.00 |