Molecular structure of FR901464, CAS Number: 146478-72-0
FR901464 (CAS 146478-72-0)
Alternate Names:
(2S,3Z)-5-{[(2R,3R,5S,6S)-6-{(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methylpenta-2,4-dien-1-yl}-2,5-dimethyltetrahydro-2H-pyran-3-yl]amino}-5-oxopent-3-en-2-yl acetate
CAS Number:
146478-72-0
Molecular Weight:
507.62
Molecular Formula:
C27H41NO8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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FR901464 (CAS 146478-72-0) References
- FR901464: total synthesis, proof of structure, and evaluation of synthetic analogues. | Thompson, CF., et al. 2001. J Am Chem Soc. 123: 9974-83. PMID: 11592876
- Cloning and elucidation of the FR901464 gene cluster revealing a complex acyltransferase-less polyketide synthase using glycerate as starter units. | Zhang, F., et al. 2011. J Am Chem Soc. 133: 2452-62. PMID: 21291275
- Sudemycins, novel small molecule analogues of FR901464, induce alternative gene splicing. | Fan, L., et al. 2011. ACS Chem Biol. 6: 582-9. PMID: 21344922
- Enantioselective syntheses of FR901464 and spliceostatin A: potent inhibitors of spliceosome. | Ghosh, AK. and Chen, ZH. 2013. Org Lett. 15: 5088-91. PMID: 24050251
- Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. | Ghosh, AK., et al. 2014. J Org Chem. 79: 5697-709. PMID: 24873648
- Splicing modulator FR901464 is a potential agent for colorectal cancer in combination therapy. | Yamano, T., et al. 2019. Oncotarget. 10: 352-367. PMID: 30719229
- Improved Synthesis of the Amine Fragment of FR901464 and Thailanstatins through the Development of a Convenient N-Detosylation Method. | Beard, JP., et al. 2022. J Org Chem. 87: 13416-13421. PMID: 36153989
- Synthesis and Conformational Analysis of FR901464-Based RNA Splicing Modulators and Their Synergism in Drug-Resistant Cancers. | Beard, JP., et al. 2023. J Med Chem. 66: 14497-14512. PMID: 37870431
- Synthesis and antiproliferative activity of a tetrahydrofuran analog of FR901464. | Pohorilets, I., et al. 2024. Bioorg Med Chem Lett. 104: 129739. PMID: 38599298
- New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. | Nakajima, H., et al. 1996. J Antibiot (Tokyo). 49: 1204-11. PMID: 9031665
Inhibitor of:
2810403A07Rik, BUD13, Cdc5L, CWC15, CWC22, FUSIP1, HEAB, hnRNP A/B, hnRNP A3, hnRNP C, hnRNP L, hnRNP Q, IQCF2, LUC7L2, MAGOH, NPWBP, Pcf11, PRP19, PRP4 kinase, PRP8, PRPF18, PRPF31, PRPF38B, RBM22, RBM34, RBM4, Sab, SAP 14_SF3B14, SAP 145, SAP 155, SAP 61, SC35, SF2/ASF, SF3B3, SFRS12, SFRS12IP1, SFRS2IP, SFRS8, Sm D3, Sm G, SmB, SMU1, SNRNP48, SNRPA, SON, splicing factor 1, SRp30a, SRp30b, Tra-2α, U11/U12 snRNP 20K, U2 snRNP B, U2AF1L3, U2AF35, U2AF65, Y14_RBM8, ZNF265, and ZRSR2.Activator of:
Gemin5, hnRNP H3, PHF5A, PRPF40B, RBM35A, RBM9, SAP 49, SF4, Sm E, SNRPC, SRm160, SRm300_Srrm2, and U2 snRNP B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FR901464, 5 mg | sc-507352 | 5 mg | $1800.00 |