Molecular structure of FR 122047 hydrochloride, CAS Number: 130717-51-0
FR 122047 hydrochloride (CAS 130717-51-0)
Alternate Names:
1-[[4,5-bis(4-methoxyphenyl)-2-thiazolyl]carbonyl]-4-methyl-piperazine
Application:
FR 122047 hydrochloride is a highly selective Cox-1 inhibitor
CAS Number:
130717-51-0
Molecular Weight:
459.99
Molecular Formula:
C23H25N3O3S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FR 122047 hydrochloride is the hydrochloride salt preparation of FR 122047 and is a Cox-1 (cyclooxygenase-1) and Cox-2 inhibitor. FR 122047 is highly selective for Cox-1 (IC50 of 0.028 μM) over Cox-2 (IC50 of 65 μM). This compound has been shown to inhibit arachidonic acid (sc-200770)-induced guinea-pig platelet aggregation in vitro. FR 122047 also displays the capacity to inhibit malondialdehyde (MDA) synthesis and cause vasodilation in vitro. Further studies suggest that FR 122047 is also capable of suppressing prostaglandin E2 (PGE2, sc-201225) and Thromboxane B2 (TXB2, sc-201452) levels which results in an anti-inflammatory effect.
FR 122047 hydrochloride (CAS 130717-51-0) References
- The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. | Ochi, T., et al. 2000. Eur J Pharmacol. 391: 49-54. PMID: 10720634
- Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. | Ochi, T. and Goto, T. 2002. Br J Pharmacol. 135: 782-8. PMID: 11834626
- Effect of acetaminophen, a cyclooxygenase inhibitor, on Morris water maze task performance in mice. | Ishida, T., et al. 2007. J Psychopharmacol. 21: 757-67. PMID: 17606472
- Participation of cyclooxygenase pathway in the vasoconstriction induced by 5-HT in the in situ autoperfused kidney of long-term diabetic rats. | Restrepo, B., et al. 2011. Eur J Pharmacol. 659: 37-44. PMID: 21414306
- The cyclooxygenase and nitric oxide synthesis/pathways mediate the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in long-term diabetic pithed rats. | Restrepo, B., et al. 2012. Pharmacology. 90: 169-76. PMID: 22948792
- Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice. | Baretella, O., et al. 2017. Acta Pharmacol Sin. 38: 498-512. PMID: 28216625
- High-Content Imaging Platform to Discover Chemical Modulators of Plasma Membrane Rafts. | Fricke, N., et al. 2022. ACS Cent Sci. 8: 370-378. PMID: 35355811
- Antiplatelet agents based on cyclooxygenase inhibition without ulcerogenesis. Evaluation and synthesis of 4,5-bis(4-methoxyphenyl)-2-substituted-thiazoles. | Tanaka, A., et al. 1994. J Med Chem. 37: 1189-99. PMID: 8164261
- The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. | Dohi, M., et al. 1993. Eur J Pharmacol. 243: 179-84. PMID: 8276067
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FR 122047 hydrochloride, 10 mg | sc-203584 | 10 mg | $161.00 | |||
FR 122047 hydrochloride, 50 mg | sc-203584A | 50 mg | $645.00 |