Molecular structure of Flunisolide, CAS Number: 3385-03-3
Flunisolide (CAS 3385-03-3)
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Alternate Names:
6-Fluoro-11,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide
CAS Number:
3385-03-3
Molecular Weight:
434.50
Molecular Formula:
C24H31FO6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Flunisolide functions as a glucocorticoid receptor agonist, binding to cytoplasmic glucocorticoid receptors and subsequently translocating to the nucleus. There, it initiates the transcription of glucocorticoid-responsive genes, including lipocortins. These lipocortins act as inhibitors of phospholipase A2, effectively blocking the release of arachidonic acid from membrane phospholipids and halting the synthesis of inflammation-mediating prostaglandins and leukotrienes. Classified as a 21-hydroxysteroid, Flunisolide belongs to the group of organic compounds that carry a hydroxyl group at the 21-position of the steroid backbone.
Flunisolide (CAS 3385-03-3) References
- A reappraisal of the clinical efficacy of nebulized flunisolide in pediatric asthma: the Italian experience. | Kantar, A., et al. 2007. Allergy Asthma Proc. 28: 671-87. PMID: 17883883
- Glucocorticoid receptor binding: a biphasic dependence on molecular size as revealed by the bilinear LinBiExp model. | Buchwald, P. 2008. Steroids. 73: 193-208. PMID: 18022656
- High-resolution mass spectrometric identification and quantification of glucocorticoid compounds in various wastewaters in the Netherlands. | Schriks, M., et al. 2010. Environ Sci Technol. 44: 4766-74. PMID: 20507090
- Modulation by flunisolide of tumor necrosis factor-alpha-induced stimulation of airway epithelial cell activities related to eosinophil inflammation. | Boero, S., et al. 2010. J Asthma. 47: 381-7. PMID: 20528590
- Olfactory drug effects approached from human-derived data. | Lötsch, J., et al. 2015. Drug Discov Today. 20: 1398-406. PMID: 26160059
- European demonstration program on the effect-based and chemical identification and monitoring of organic pollutants in European surface waters. | Tousova, Z., et al. 2017. Sci Total Environ. 601-602: 1849-1868. PMID: 28629112
- Intranasal Flunisolide Suppresses Pathological Alterations Caused by Silica Particles in the Lungs of Mice. | Ferreira, TPT., et al. 2020. Front Endocrinol (Lausanne). 11: 388. PMID: 32625168
- What makes flunisolide different among inhaled corticosteroids used for nebulization: a close look at the role of aqueous solubility. | Kantar, A. 2021. Multidiscip Respir Med. 16: 719. PMID: 33489120
- Supercritical CO2 Extraction of Organic Solvents from Flunisolide and Fluticasone Propionate. | Baldino, L., et al. 2021. Pharmaceutics. 13: PMID: 33922659
- Adsorption kinetics of 20 glucocorticoids at environmentally relevant concentrations in wastewater by powdered activated carbons and development of surrogate models. | Zhang, A., et al. 2022. J Water Process Eng. 50: 103279. PMID: 36349294
- Global occurrence of synthetic glucocorticoids and glucocorticoid receptor agonistic activity, and aquatic hazards in effluent discharges and freshwater systems. | Cole, AR. and Brooks, BW. 2023. Environ Pollut. 329: 121638. PMID: 37080519
- Disposition of flunisolide in the rat, mouse, dog, rhesus monkey, and cynomolgus monkey. | Chu, NI., et al. 1979. Drug Metab Dispos. 7: 81-9. PMID: 38078
- Variations in reproductive and developmental toxicant identification | Quigley, D., Simmons, F., Whyte, H., Robertson, J., & Freshwater, D. 2010. Journal of Chemical Health & Safety. 17(1): 29-53.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flunisolide, 100 mg | sc-215039 | 100 mg | $110.00 | |||
Flunisolide, 500 mg | sc-215039A | 500 mg | $434.00 |