Feglymycin (CAS 209335-49-9)

Feglymycin, identified by the CAS number 209335-49-9, is a naturally occurring peptide antibiotic that is distinguished by its unique structure consisting of multiple glycine residues and non-proteinogenic amino acids. This compound operates primarily through a novel mechanism of action involving the inhibition of the interaction between bacterial proteins and their corresponding DNA sequences. Specifically, feglymycin targets the DNA-binding domains of certain bacterial transcription factors, thereby preventing these proteins from attaching to their DNA motifs. This disruption impedes the transcription process crucial for bacterial cell function and replication. In research settings, feglymycin has been extensively studied for its role in elucidating the fundamental processes of bacterial gene regulation and protein-DNA interactions. The ability of feglymycin to selectively bind to specific components of the bacterial transcription machinery makes it a valuable tool for scientists exploring the intricacies of bacterial gene expression and the potential mechanisms by which bacteria regulate their response to environmental changes. Additionally, the study of feglymycin contributes to the broader understanding of peptide antibiotics′ structure-activity relationships, providing insights that could guide the synthesis of new compounds aimed at modulating protein-DNA interactions in various biomedical research applications.