Fe(III) Mesoporphyrin IX chloride
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Fe(III) Mesoporphyrin IX chloride is a compound that functions as a potent inhibitor of heme oxygenase. It acts by binding to the active site of heme oxygenase, preventing the enzymatic conversion of heme to biliverdin, carbon monoxide, and free iron. This inhibition disrupts the normal breakdown of heme, leading to an accumulation of heme and a decrease in the production of biliverdin and carbon monoxide. As a result, Fe(III) Mesoporphyrin IX chloride effectively interferes with the normal physiological processes regulated by heme oxygenase. Its mechanism of action involves disrupting the enzymatic activity of heme oxygenase, thereby influencing the balance of heme and its metabolic by-products within the cellular environment. Fe(Iii) Mesoporphyrin Ix Chloride′s ability to inhibit heme oxygenase may be for studying the role of heme metabolism in various experimental applications.
Fe(III) Mesoporphyrin IX chloride References
- The role of an amino acid triad at the entrance of the heme pocket in human serum albumin for O(2) and CO binding to iron protoporphyrin IX. | Komatsu, T., et al. 2009. Org Biomol Chem. 7: 3836-41. PMID: 19707690
- First observation in the gas phase of the ultrafast electronic relaxation pathways of the S(2) states of heme and hemin. | Ha-Thi, MH., et al. 2010. Phys Chem Chem Phys. 12: 14985-93. PMID: 20949219
- Proton-coupled electron transfer reactions at a heme-propionate in an iron-protoporphyrin-IX model compound. | Warren, JJ. and Mayer, JM. 2011. J Am Chem Soc. 133: 8544-51. PMID: 21524059
- Gallium(III), cobalt(III) and copper(II) protoporphyrin IX exhibit antimicrobial activity against Porphyromonas gingivalis by reducing planktonic and biofilm growth and invasion of host epithelial cells. | Olczak, T., et al. 2012. Arch Microbiol. 194: 719-24. PMID: 22447101
- Photoreduction of iron protoporphyrin IX chloride in ionic detergent micelles probed by resonance Raman spectroscopy | and P. K. Shantha, G. S. S. Saini, H. H. Thanga, A. L. Verma. 2003. Journal of Raman Spectroscopy. 34: 315-321.
- Determination of Hemin using a Parallel Catalytic Reduction Wave of its Protoporphyrin IX Ring | Dajun Xu and & Dengbai Luo. 2007. Analytical Letters. 40: 3060-3069.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fe(III) Mesoporphyrin IX chloride, 50 mg | sc-396889 | 50 mg | $200.00 | |||
Fe(III) Mesoporphyrin IX chloride, 100 mg | sc-396889A | 100 mg | $300.00 |