ExoC3L2 Antibody (H-5): sc-393332
- ExoC3L2 Antibody (H-5) is a mouse monoclonal IgG1 κ ExoC3L2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 97-124 within an internal region of ExoC3L2 of human origin
- ExoC3L2 Antibody (H-5) is recommended for detection of ExoC3L2 of human origin by WB, IP, IF and ELISA
- Anti-ExoC3L2 Antibody (H-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for ExoC3L2 Antibody (H-5) for WB applications. This reagent is now offered in a bundle with ExoC3L2 Antibody (H-5) (see ordering information below).
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ExoC3L2 Antibody (H-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects ExoC3L2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ExoC3L2 (H-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ExoC3L2, also known as HBV X-transactivated gene 7 protein, plays a significant role in the exocyst complex, which is essential for the proper targeting of exocytic vesicles to specific docking sites on the plasma membrane. This complex is crucial for exocytosis, a process that facilitates the secretion of hormones and neurotransmitters, as well as the incorporation of membrane proteins and lipids into the plasma membrane, thereby influencing cell-cell communication, growth, and polarity. The exocyst complex is composed of several proteins, including Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70, and Exo84, and has been shown to inhibit tubulin polymerization in vitro, indicating its role in modulating microtubule dynamics that are vital for exocytosis. With its 409 amino acid structure, ExoC3L2 is closely related to the Sec6 component of the exocyst complex, highlighting its importance in cellular processes and potential implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ExoC3L2 Antibody (H-5) References:
- Targeting vesicles to specific sites on the plasma membrane: the role of the sec6/8 complex. | Hsu, SC., et al. 1999. Trends Cell Biol. 9: 150-3. PMID: 10203793
- The Sec6/8 complex in mammalian cells: characterization of mammalian Sec3, subunit interactions, and expression of subunits in polarized cells. | Matern, HT., et al. 2001. Proc Natl Acad Sci U S A. 98: 9648-53. PMID: 11493706
- Complete sequencing and characterization of 21,243 full-length human cDNAs. | Ota, T., et al. 2004. Nat Genet. 36: 40-5. PMID: 14702039
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
- Surprising twists to exocyst function. | Clandinin, TR. 2005. Neuron. 46: 164-6. PMID: 15848794
- The exocyst complex in polarized exocytosis. | He, B. and Guo, W. 2009. Curr Opin Cell Biol. 21: 537-42. PMID: 19473826
- An old dog learns new tricks: novel functions of the exocyst complex in polarized epithelia in animals. | Kang, RS. and Fölsch, H. 2009. F1000 Biol Rep. 1: 83. PMID: 20161436
- Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. | TerBush, DR. and Novick, P. 1995. J Cell Biol. 130: 299-312. PMID: 7615633
- Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. | Grindstaff, KK., et al. 1998. Cell. 93: 731-40. PMID: 9630218
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ExoC3L2 Antibody (H-5) | sc-393332 | 200 µg/ml | $322.00 | |||
ExoC3L2 Antibody (H-5): m-IgG1 BP-HRP Bundle | sc-531757 | 200 µg Ab; 20 µg BP | $361.00 | |||
ExoC3L2 Antibody (H-5) AC | sc-393332 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ExoC3L2 Antibody (H-5) HRP | sc-393332 HRP | 200 µg/ml | $322.00 | |||
ExoC3L2 Antibody (H-5) FITC | sc-393332 FITC | 200 µg/ml | $336.00 | |||
ExoC3L2 Antibody (H-5) PE | sc-393332 PE | 200 µg/ml | $349.00 | |||
ExoC3L2 Antibody (H-5) Alexa Fluor® 488 | sc-393332 AF488 | 200 µg/ml | $364.00 | |||
ExoC3L2 Antibody (H-5) Alexa Fluor® 546 | sc-393332 AF546 | 200 µg/ml | $364.00 | |||
ExoC3L2 Antibody (H-5) Alexa Fluor® 594 | sc-393332 AF594 | 200 µg/ml | $364.00 | |||
ExoC3L2 Antibody (H-5) Alexa Fluor® 647 | sc-393332 AF647 | 200 µg/ml | $364.00 | |||
ExoC3L2 Antibody (H-5) Alexa Fluor® 680 | sc-393332 AF680 | 200 µg/ml | $364.00 | |||
ExoC3L2 Antibody (H-5) Alexa Fluor® 790 | sc-393332 AF790 | 200 µg/ml | $364.00 | |||
ExoC3L2 (H-5) Neutralizing Peptide | sc-393332 P | 100 µg/0.5 ml | $69.00 |