Molecular structure of Etoposide Phosphate, CAS Number: 117091-64-2
Etoposide Phosphate (CAS 117091-64-2)
See product citations (3)
Alternate Names:
Eposin; Etopophos; Vepesid; VP-16
Application:
Etoposide Phosphate is a topoisomerase II inhibitor inspired by podophyllotoxin
CAS Number:
117091-64-2
Purity:
≥98%
Molecular Weight:
668.53
Molecular Formula:
C29H33O16P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Etoposide Phosphate is a derivative of Etoposide (VP-16) (sc-3512). Etoposide is a topoisomerase II inhibitor that is widely used as an apoptosis inducer. Etoposide exhibits antineoplastic and anti-mitotic properties. Inhibits DNA synthesis and induces double-strand and single-strand DNA breaks. Cell-cycle dependent and cell-cycle specific to late S and G2 phases. Activates p53 resulting in upregulated expression of TRAIL-R2 (DR5) and Bak to overcome TRAIL resistance in Bax-deficient human colon carcinoma cancer cells. Etoposide Phosphate is an activator of p53.
Etoposide Phosphate (CAS 117091-64-2) References
- Physical and chemical stability of etoposide phosphate solutions. | Zhang, Y. and Trissel, LA. 1999. J Am Pharm Assoc (Wash). 39: 146-50. PMID: 10079650
- Unexpected neurotoxicity of etoposide phosphate administered in combination with other chemotherapeutic agents after blood-brain barrier modification to enhance delivery, using propofol for general anesthesia, in a rat model. | Fortin, D., et al. 2000. Neurosurgery. 47: 199-207. PMID: 10917363
- Etoposide phosphate enhances the acetylation level of translation elongation factor 1A in PLC5 cells. | Hu, JL., et al. 2012. Z Naturforsch C J Biosci. 67: 327-30. PMID: 22888539
- The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting G1-S-phase transition and inducing apoptosis. | Fan, L., et al. 2017. Oncotarget. 8: 47250-47268. PMID: 28467790
- Dose escalation study to evaluate safety, tolerability and efficacy of intravenous etoposide phosphate administration in 27 dogs with multicentric lymphoma. | Boyé, P., et al. 2017. PLoS One. 12: e0177486. PMID: 28505195
- Chemotherapy induces ovarian cancer cell repopulation through the caspase 3-mediated arachidonic acid metabolic pathway. | Cui, L., et al. 2017. Onco Targets Ther. 10: 5817-5826. PMID: 29263678
- Physicochemical stability of etoposide diluted at range concentrations between 0.38 and 1.75 mg/mL in polyolefin bags. | D'Huart, E., et al. 2020. Eur J Hosp Pharm. 27: 43-48. PMID: 32064088
- Randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared with etoposide phosphate, in dogs with naturally occurring lymphoma. | Boyé, P., et al. 2020. Oncotarget. 11: 671-686. PMID: 32133044
- Prognostic value of pretreatment plasma D-dimer level in dogs with intermediate to high-grade non-Hodgkin lymphoma. | Boyé, P., et al. 2021. Vet Comp Oncol. 19: 44-52. PMID: 32643242
- Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma. | Schwinn, S., et al. 2021. Sci Rep. 11: 14062. PMID: 34234256
- Immediate severe hypersensitivity reaction to etoposide phosphate: Case report and review of the literature. | Pringle, NR., et al. 2022. J Oncol Pharm Pract. 28: 1019-1023. PMID: 35037804
- Assessment of toxicokinetics and toxicodynamics following intravenous administration of etoposide phosphate in beagle dogs. | Igwemezie, LN., et al. 1995. Pharm Res. 12: 117-23. PMID: 7724471
- Etoposide- and BMY-40481-induced sensory neuropathy in mice. | Bregman, CL., et al. 1994. Toxicol Pathol. 22: 528-35. PMID: 7899782
Inhibitor of:
Topo II.Activator of:
p53.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Etoposide Phosphate, 25 mg | sc-357357 | 25 mg | $143.00 | |||
Etoposide Phosphate, 100 mg | sc-357357A | 100 mg | $362.00 | |||
Etoposide Phosphate, 250 mg | sc-357357B | 250 mg | $851.00 | |||
Etoposide Phosphate, 1 g | sc-357357C | 1 g | $1706.00 |