Ethyl-3,4-Dephostatin MF: C8H10N2O3
MW: 182.18
A potent inhibitor of protein tyrosine phosphatase 1B.

Ethyl-3,4-Dephostatin

Ethyl-3,4-Dephostatin is rated 5.0 out of 5 by 1.
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Application: A potent inhibitor of protein tyrosine phosphatase 1B
Purity: ≥99%
Molecular Weight: 182.18
Molecular Formula: C8H10N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ethyl-3,4-Dephostatin is a more stable ethyl analog of 3,4-Dephostatin. Ethyl-3,4-Dephostatin potently inhibits PTP1B (protein tyrosine phosphatase 1B). Ethyl-3,4-Dephostatin is an inhibitor of SH-PTP1.


References

Suzuki, T., et al. 2001. J. Biol. Chem. 276, 27511. Watanabe, T., et al. 2000. Tetrahedron 56, 741.

Physical State :
Solid
Solubility :
Soluble in DMSO (22 mg/mL), water (8 mg/mL), and methanol (50 mg/mL).
Storage :
Store at 4° C
Melting Point :
130° C
Boiling Point :
444.70° C at 760 mmHg (Predicted)
Density :
1.31 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
IC50 :
protein tyrosine phosphatase 1B: IC50 = 3.2 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
10352315
MDL Number :
MFCD04040000
SMILES :
CCN(C1=CC(=O)C(=O)C=C1)NO

Download SDS (MSDS)

Certificate of Analysis

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Ethyl-3,4-Dephostatin  Product Citations

See how others have used Ethyl-3,4-Dephostatin. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23579275  Kim, JH. et al. 2013. Cell Death Dis. 4: e588.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Ethyl Ethyl-3,4-Dephostatin was found to inhibit the action of lambda protein phosphatase. This was demonstrated by IF showing nuclear localization and increase in signal of phosphorylated NFkB p50 in the treated NIH/3T3 cells. -SCBT QC
Date published: 2015-04-13
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