Ethyl-3,4-Dephostatin
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Ethyl-3,4-dephostatin is a potent and selective inhibitor known for its intriguing mechanism of action, primarily targeting protein tyrosine phosphatases (PTPs). By inhibiting PTPs, it plays a role in modulating cellular signaling pathways that are fundamental to various biological processes, including cell growth, differentiation, and metabolic control. Its specificity and efficacy in inhibiting these enzymes make it useful in biochemical research, offering insights into the intricate regulatory mechanisms that govern cellular function. Researchers leverage ethyl-3,4-dephostatin in experimental applications to elucidate the roles of PTPs in signaling pathways, providing a deeper understanding of cellular dynamics and contributing to the development of novel research methodologies. Its application in the study of enzyme kinetics and signaling pathway analysis exemplifies its significance in advancing the field of molecular biology and biochemistry.
Ethyl-3,4-Dephostatin References
- Requirement of protein tyrosine kinase and phosphatase activities for human sperm exocytosis. | Tomes, CN., et al. 2004. Dev Biol. 265: 399-415. PMID: 14732401
- Nerve growth factor-independent neuronal survival: a role for NO donors. | Akassoglou, K. 2005. Mol Pharmacol. 68: 952-5. PMID: 16046659
- Inhibition of dual-specificity phosphatase 26 by ethyl-3,4-dephostatin: Ethyl-3,4-dephostatin as a multiphosphatase inhibitor. | Seo, H. and Cho, S. 2016. Pharmazie. 71: 196-200. PMID: 27209699
- Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking. | Ren, JX., et al. 2017. Biomed Pharmacother. 89: 376-385. PMID: 28249240
- Cysteine modifiers suggest an allosteric inhibitory site on the CAL PDZ domain. | Zhao, Y., et al. 2018. Biosci Rep. 38: PMID: 29472314
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ethyl-3,4-Dephostatin, 1 mg | sc-220886 | 1 mg | $215.00 |