Molecular structure of Equisetin, CAS Number: 57749-43-6
Equisetin (CAS 57749-43-6)
See product citations (4)
Alternate Names:
LS-64262
Application:
Equisetin is a tetramic acid with antibiotic and cytotoxic activity, and a potent inhibitor of HIV-1 integrase
CAS Number:
57749-43-6
Purity:
>99%
Molecular Weight:
373.5
Molecular Formula:
C22H31NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Equisetin is an N-methylserine-derived acyl tetramic acid produced by a number of Fusarium species with antibiotic and cytotoxic activity. The compound has displayed inhibitory activity against mitochondrial ATPases and HIV-1 integrase in vitro. In a study of mitochondrial inorganic pyrophosphatase (PPase) in the yeast Saccharomyces cerevisiae, Equisetin is observed to increase mitochondrial PPase activity several folds. Data has shown that Equisetin specifically inhibits the substrate anion carriers of the inner membrane of mitochondria while acts nonspecifically on protein membranes and protein hydrophobic domains.
Equisetin (CAS 57749-43-6) References
- A short stereoselective total synthesis of the fusarium toxin equisetin. | Burke, LT., et al. 2000. Org Lett. 2: 3611-3. PMID: 11073657
- Characterization of a mitochondrial inorganic pyrophosphatase in Saccharomyces cerevisiae. | Lundin, M., et al. 1992. Biochim Biophys Acta. 1098: 217-23. PMID: 1309654
- Equisetin biosynthesis in Fusarium heterosporum. | Sims, JW., et al. 2005. Chem Commun (Camb). 186-8. PMID: 15724180
- Antibiotic produced by Fusarium equiseti NRRL 5537. | Burmeister, HR., et al. 1974. Antimicrob Agents Chemother. 5: 634-9. PMID: 15825417
- Molecular biology of Fusarium mycotoxins. | Desjardins, AE. and Proctor, RH. 2007. Int J Food Microbiol. 119: 47-50. PMID: 17707105
- Phoma Saccardo: distribution, secondary metabolite production and biotechnological applications. | Rai, M., et al. 2009. Crit Rev Microbiol. 35: 182-96. PMID: 19624254
- The effect of equisetin on energy-linked reactions in Rhodospirillum rubrum chromatophores. | Nyrén, P. and Strid, A. 1989. Arch Biochem Biophys. 268: 659-66. PMID: 2536535
- Chemo-enzymatic synthesis of equisetin. | Li, X., et al. 2017. Chem Commun (Camb). 53: 4695-4697. PMID: 28401214
- Equisetin as potential quorum sensing inhibitor of Pseudomonas aeruginosa. | Zhang, M., et al. 2018. Biotechnol Lett. 40: 865-870. PMID: 29502217
- Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase. | Larson, EC., et al. 2020. PLoS One. 15: e0233485. PMID: 32470050
- Crystal Structures of Fsa2 and Phm7 Catalyzing [4 + 2] Cycloaddition Reactions with Reverse Stereoselectivities in Equisetin and Phomasetin Biosynthesis. | Chi, C., et al. 2021. ACS Omega. 6: 12913-12922. PMID: 34056443
- Equisetin Restores Colistin Sensitivity against Multi-Drug Resistant Gram-Negative Bacteria. | Zhang, Q., et al. 2021. Antibiotics (Basel). 10: PMID: 34680843
- Equisetin is an anti-obesity candidate through targeting 11β-HSD1. | Xu, Z., et al. 2022. Acta Pharm Sin B. 12: 2358-2373. PMID: 35646525
- Equisetin Targets Intracellular Staphylococcus aureus through a Host Acting Strategy. | Tian, J., et al. 2022. Mar Drugs. 20: PMID: 36354979
- Effects of equisetin on rat liver mitochondria: evidence for inhibition of substrate anion carriers of the inner membrane. | König, T., et al. 1993. J Bioenerg Biomembr. 25: 537-45. PMID: 8132493
Inhibitor of:
ATPase, and HIV-1 Integrase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Equisetin, 1 mg | sc-202153 | 1 mg | $153.00 |