Molecular structure of Epothilone B, CAS Number: 152044-54-7
Epothilone B (CAS 152044-54-7)
Application:
Epothilone B is a microtubule stabilizer
CAS Number:
152044-54-7
Purity:
98%
Molecular Weight:
507.68
Molecular Formula:
C27H41NO6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Epothilone B is a 16-membered macrolide that displays microtubule stabilizing properties. Studies have shown that Epothilone B induces tubulin polymerization into microtubules in vitro. Additional experiments suggest that Epothilone B causes cell cycle arrest at the G2 stage and eventually leads to cytotoxicity. EPB′s mechanism of action closely resembles that of paclitaxel. By binding to microtubule tubulin dimers, EPB prevents their depolymerization, ultimately leading to cell death.
Epothilone B (CAS 152044-54-7) References
- New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. | Hardt, IH., et al. 2001. J Nat Prod. 64: 847-56. PMID: 11473410
- Epothilone B inhibits neointimal formation after rat carotid injury through the regulation of cell cycle-related proteins. | Lim, Y., et al. 2007. J Pharmacol Exp Ther. 321: 648-55. PMID: 17289837
- The microtubule inhibiting agent epothilone B antagonizes glioma cell motility associated with reorganization of the actin-binding protein α-actinin 4. | Henry, WI., et al. 2011. Oncol Rep. 25: 887-93. PMID: 21234524
- Epothilone B induces apoptosis and enhances apoptotic effects of ABT-737 on human cancer cells via PI3K/AKT/mTOR pathway. | Li, YL., et al. 2016. J Cancer Res Clin Oncol. 142: 2281-9. PMID: 27591861
- Epothilone B-based 3-in-1 polymeric micelle for anticancer drug therapy. | Shin, DH. and Kwon, GS. 2017. Int J Pharm. 518: 307-311. PMID: 28062368
- Synthesis, anticancer activity and cytotoxicity of galactosylated epothilone B. | Gao, H. and Huang, G. 2018. Bioorg Med Chem. 26: 5578-5581. PMID: 30318441
- Microtubule stabilizer epothilone B as a motor neuron differentiation agent for human endometrial stem cells. | Mahmoodi, N., et al. 2020. Cell Biol Int. 44: 1168-1183. PMID: 32022385
- ROS-Responsive Nanoparticles Formed from RGD-Epothilone B Conjugate for Targeted Cancer Therapy. | Xia, X., et al. 2020. ACS Appl Mater Interfaces. 12: 18301-18308. PMID: 32242653
- Epothilone B prevents lipopolysaccharide-induced inflammatory osteolysis through suppressing osteoclastogenesis via STAT3 signaling pathway. | Chen, Y., et al. 2020. Aging (Albany NY). 12: 11698-11716. PMID: 32527985
- Epothilone B Facilitates Peripheral Nerve Regeneration by Promoting Autophagy and Migration in Schwann Cells. | Zhou, J., et al. 2020. Front Cell Neurosci. 14: 143. PMID: 32528253
- Heterologous redox partners supporting the efficient catalysis of epothilone B biosynthesis by EpoK in Schlegelella brevitalea. | Liang, J., et al. 2020. Microb Cell Fact. 19: 180. PMID: 32933531
- Docking-guided rational engineering of a macrolide glycosyltransferase glycodiversifies epothilone B. | Zhang, P., et al. 2022. Commun Biol. 5: 100. PMID: 35087210
- System analysis based on the pyroptosis-related genes identifies GSDMC as a novel therapy target for pancreatic adenocarcinoma. | Yan, C., et al. 2022. J Transl Med. 20: 455. PMID: 36199146
- Epothilone B inactivation of Sirtuin1 promotes mitochondrial reactive oxygen species to induce dysfunction and ferroptosis of Schwann cells. | Liang, Z., et al. 2023. Eur J Pharm Sci. 181: 106350. PMID: 36496165
- Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action. | Bollag, DM., et al. 1995. Cancer Res. 55: 2325-33. PMID: 7757983
Inhibitor of:
Tubulin.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Epothilone B, 100 µg | sc-207629 | 100 µg | $295.00 |