Enviroxime (CAS 72301-79-2)
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Enviroxime is a benzimidazole derivative that inhibits rhinovirus multiplication. Enviroxime is an antiviral agent that is effective against rhinoviruses and enteroviruses. It inhibits plaque formation induced by coxsackievirus B3, rhinovirus, and poliovirus in HeLa monolayer cell cultures at concentrations of 0.1, 1, and 10 µg/ml. It also inhibits production of poliovirus PV1 viral RNA in HeLa monolayer cell cultures at a concentration of 1 µg/ml. Additionally, it reduces viral titers in DRAW macrophages infected with the DA strain of Theiler′s murine encephalomyelitis virus. Enviroxime is a substituted benzimidazole derivative that works by inhibiting viral protein 3A and 3AB, which are involved in the formation of the viral RNA replication complex, thus leading to the suppression of viral replication.
Enviroxime (CAS 72301-79-2) References
- Evidence that enviroxime targets multiple components of the rhinovirus 14 replication complex. | Brown-Augsburger, P., et al. 1999. Arch Virol. 144: 1569-85. PMID: 10486111
- Cytotoxicity of the synergistic antienteroviral combination of enviroxime and disoxaril. | Nikolaeva, L. and Galabov, AS. 1999. Acta Virol. 43: 263-5. PMID: 10749374
- In vitro inhibitory effects of dual combinations of picornavirus replication inhibitors. | Nikolaeva, L. and Galabov, AS. 1999. Acta Virol. 43: 303-11. PMID: 10757231
- Antiviral effect of the combination of enviroxime and disoxaril on coxsackievirus B1 infection. | Nikolaeva, L. and Galabov, AS. 2000. Acta Virol. 44: 73-8. PMID: 10989697
- Cellular kinase inhibitors that suppress enterovirus replication have a conserved target in viral protein 3A similar to that of enviroxime. | Arita, M., et al. 2009. J Gen Virol. 90: 1869-1879. PMID: 19439558
- Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. | Arita, M., et al. 2011. J Virol. 85: 2364-72. PMID: 21177810
- Liposomes of enviroxime and phosphatidylcholine: definition of the drug-phospholipid interactions. | Garcon, NM., et al. 1989. Antiviral Res. 11: 89-98. PMID: 2729956
- Activity against rhinoviruses, toxicity, and delivery in aerosol of enviroxime in liposomes. | Wyde, PR., et al. 1988. Antimicrob Agents Chemother. 32: 890-5. PMID: 2843086
- Comparative studies on the modes of action of the antirhinovirus agents Ro 09-0410, Ro 09-0179, RMI-15,731, 4',6-dichloroflavan, and enviroxime. | Ninomiya, Y., et al. 1985. Antimicrob Agents Chemother. 27: 595-9. PMID: 2988431
- PI4KIII inhibitor enviroxime impedes the replication of the hepatitis C virus by inhibiting PI3 kinases. | Delang, L., et al. 2018. J Antimicrob Chemother. 73: 3375-3384. PMID: 30219827
- Small particle aerosols of enviroxime-containing liposomes. | Gilbert, BE., et al. 1988. Antiviral Res. 9: 355-65. PMID: 3228281
- The antiviral compound enviroxime targets the 3A coding region of rhinovirus and poliovirus. | Heinz, BA. and Vance, LM. 1995. J Virol. 69: 4189-97. PMID: 7769678
- Synthesis, antiviral activity, and biological properties of vinylacetylene analogs of enviroxime. | Victor, F., et al. 1997. J Med Chem. 40: 1511-8. PMID: 9154972
- Synthesis and antiviral activity of C2 analogs of enviroxime: an exploration of the role of critical functionality. | Victor, F., et al. 1997. J Med Chem. 40: 3478-83. PMID: 9341923
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Enviroxime, 1 mg | sc-498623A | 1 mg | $149.00 | |||
Enviroxime, 10 mg | sc-498623 | 10 mg | $424.00 |