Molecular structure of Enopeptin A, CAS Number: 139601-96-0
Enopeptin A (CAS 139601-96-0)
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Alternate Names:
Enopeptin II; BRN 5373924; NSC657143
Application:
Enopeptin A is an antiviral compound which can disregulate Clp-family proteins
CAS Number:
139601-96-0
Purity:
≥95%
Molecular Weight:
896.00
Molecular Formula:
C47H57N7O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Enopeptin A is an unusual depsipeptide featuring a pentaenone side chain, reported as an antiviral by researchers at RIKEN in 1991. Enopeptin A has potent antibacterial activity against Gram positive and Gram negative bacteria, including MRSA. Enopeptin A is the most non-polar of the acyldepsipeptide (ADEP) antibiotics which include the recently rediscovered compounds, A54556 A (sc-397312) and B, that act by activating and disregulating Clp-family proteins.
Enopeptin A (CAS 139601-96-0) References
- Occurrence of two 5-aminolevulinate biosynthetic pathways in Streptomyces nodosus subsp. asukaensis is linked with the production of asukamycin. | Petrícek, M., et al. 2006. J Bacteriol. 188: 5113-23. PMID: 16816183
- Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity. | Osada, H., et al. 1991. J Antibiot (Tokyo). 44: 1463-6. PMID: 1778798
- Restriction of the conformational dynamics of the cyclic acyldepsipeptide antibiotics improves their antibacterial activity. | Carney, DW., et al. 2014. J Am Chem Soc. 136: 1922-9. PMID: 24422534
- Hyaluromycin, a new hyaluronidase inhibitor of polyketide origin from marine Streptomyces sp. | Harunari, E., et al. 2014. Mar Drugs. 12: 491-507. PMID: 24451191
- Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics. | Koopmanschap, G., et al. 2014. Beilstein J Org Chem. 10: 544-98. PMID: 24605172
- Total synthesis and antibacterial testing of the A54556 cyclic acyldepsipeptides isolated from Streptomyces hawaiiensis. | Goodreid, JD., et al. 2014. J Nat Prod. 77: 2170-81. PMID: 25255326
- A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus. | Arvanitis, M., et al. 2016. PLoS One. 11: e0153912. PMID: 27101010
- Solution conformation of enopeptin A, a depsipeptide antibiotic, using 2D NMR and restrained molecular dynamics studies. | Young, JJ., et al. 1994. J Antibiot (Tokyo). 47: 922-31. PMID: 7928680
- A unique phenylalanine-containing lipopeptide isolated from a rough-colony variant of Mycobacterium avium. | Rivière, M., et al. 1996. Eur J Biochem. 241: 682-90. PMID: 8917472
- Factumycin and its new derivative RK-1009 enhance threonine-phosphorylation of a 60-kDa protein in Streptomyces griseus. | Kakeya, H., et al. 1998. J Antibiot (Tokyo). 51: 963-6. PMID: 9917012
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Enopeptin A, 0.5 mg | sc-397311 | 0.5 mg | $340.00 | |||
Enopeptin A, 2.5 mg | sc-397311A | 2.5 mg | $920.00 |