Elvitegravir CAS: 697761-98-1
MF: C23H23ClFNO5
MW: 447.88
An HIV-1 integrase inhibitor.

Elvitegravir (CAS 697761-98-1)

Elvitegravir | CAS 697761-98-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Application: Elvitegravir is An HIV-1 integrase inhibitor.
CAS Number: 697761-98-1
Molecular Weight: 447.88
Molecular Formula: C23H23ClFNO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Elvitegravir is an inhibitor of HIV-1 integrase which is responsible for the strand-transfer step of integration. Studies indicate that Elvitegravir is effective against HIV-1 strains that are resistant to other agents such as nucleotide reverse-transcriptase inhibitors (NRTIs), nonnucleoside reverse-transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs), as a result of Elvitegravir's ability to block the function of HIV1 integrase.


References

1. Zolopa, A.R., et al. 2010. J. Infect. Dis. 201: 814-822. PMID: 20146631

Physical State :
Solid
Storage :
Store at 4° C
Melting Point :
93-96° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23083982
SMILES :
CC(C)C(CO)N1C=C(C(=O)C2=CC(=C(C=C21)OC)CC3=C(C(=CC=C3)Cl)F)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Elvitegravir (CAS 697761-98-1)  Product Citations

See how others have used Elvitegravir (CAS 697761-98-1). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 30919089  Leporati, A. et al. 2019. Pharm. Res. 36: 73.

PMID: # 26898957  Mitsuki, YY. et al. 2016. Journal of virological methods. 231: 25-33.

PMID: # 24594066  Shadrina, O. et al. 2014. Biochimie. 102: 92-101.

PMID: # 21060108  Koh, Y. et al. 2011. Antimicrob. Agents Chemother. 55: 42-9.

PMID: # 25927004  Shadrina, OA. et al. Acta Naturae. 7: 78-86.

Citations 1 to 5 of 5 total

It would be great if you could add the solubility information for this.

Asked by: tpietka
Thank you for your question. This compound is soluble in DMSO at a concentration of up to 90 mg/mL (200.94 mM), in ethanol at up to 35 mg/mL (78.14 mM) and is insoluble to very slightly soluble in water - <1 mg/mL (<1 mM).
Answered by: Tech Support Europe
Date published: 2020-08-11

Is Elivitegravir the same chemical as Dolutegravir? I am looking for dolutegravir 10 g

Asked by: Dana S
Thank you for your question. The two compounds are not the same. Dolutegravir has CAS number 1051375-16-6, while Elvitegravir has CAS number 697761-98-1. We offer Dolutegravir under its alternative name, S/GSK1349572, with the corresponding product code sc-364605. Please contact customer care so we can send you a quote for the quantity you require.
Answered by: Tech Support Europe
Date published: 2020-07-30
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Rated 5 out of 5 by from Nabekura Nabekura, T. et al. (PubMed 26416870) reported that the antiviral Elvitegravir inhibited organic anion transport in human placental BeWo cells. -SCBT Publication Review
Date published: 2015-05-05
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