Elvitegravir is an inhibitor of HIV-1 integrase which is responsible for the strand-transfer step of integration. Studies indicate that Elvitegravir is effective against HIV-1 strains that are resistant to other agents such as nucleotide reverse-transcriptase inhibitors (NRTIs), nonnucleoside reverse-transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs), as a result of Elvitegravir's ability to block the function of HIV1 integrase.
1. Zolopa, A.R., et al. 2010. J. Infect. Dis. 201: 814-822. PMID: 20146631
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It would be great if you could add the solubility information for this.
Asked by: tpietka
Thank you for your question. This compound is soluble in DMSO at a concentration of up to 90 mg/mL (200.94 mM), in ethanol at up to 35 mg/mL (78.14 mM) and is insoluble to very slightly soluble in water - <1 mg/mL (<1 mM).
Answered by: Tech Support Europe
Date published: 2020-08-11
Is Elivitegravir the same chemical as Dolutegravir? I am looking for dolutegravir 10 g
Asked by: Dana S
Thank you for your question. The two compounds are not the same. Dolutegravir has CAS number 1051375-16-6, while Elvitegravir has CAS number 697761-98-1. We offer Dolutegravir under its alternative name, S/GSK1349572, with the corresponding product code sc-364605.
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NabekuraNabekura, T. et al. (PubMed 26416870) reported that the antiviral Elvitegravir inhibited organic anion transport in human placental BeWo cells. -SCBT Publication Review
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