Date published: 2025-10-8

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Elvitegravir (CAS 697761-98-1)

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Alternate Names:
6-[(3-chloro-2-fluorophenyl)methyl]-1-[(2S)-1-hydroxy-3-methylbutan-2-yl]-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Application:
Elvitegravir is An HIV-1 integrase inhibitor.
CAS Number:
697761-98-1
Molecular Weight:
447.88
Molecular Formula:
C23H23ClFNO5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Elvitegravir is an inhibitor of HIV-1 integrase which is responsible for the strand-transfer step of integration. Studies indicate that Elvitegravir is effective against HIV-1 strains that are resistant to other agents such as nucleotide reverse-transcriptase inhibitors (NRTIs), nonnucleoside reverse-transcriptase inhibitors (NNRTIs), and protease inhibitors (PIs), as a result of Elvitegravir′s ability to block the function of HIV1 integrase.


Elvitegravir (CAS 697761-98-1) References

  1. Elvitegravir: a new HIV integrase inhibitor.  |  Shimura, K. and Kodama, EN. 2009. Antivir Chem Chemother. 20: 79-85. PMID: 19843978
  2. Pharmacokinetic interaction of ritonavir-boosted elvitegravir and maraviroc.  |  Ramanathan, S., et al. 2010. J Acquir Immune Defic Syndr. 53: 209-14. PMID: 19851115
  3. Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV Type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial.  |  Zolopa, AR., et al. 2010. J Infect Dis. 201: 814-22. PMID: 20146631
  4. Elvitegravir overcomes resistance to raltegravir induced by integrase mutation Y143.  |  Métifiot, M., et al. 2011. AIDS. 25: 1175-8. PMID: 21505303
  5. In vitro resistance selections using elvitegravir, raltegravir, and two metabolites of elvitegravir M1 and M4.  |  Margot, NA., et al. 2012. Antiviral Res. 93: 288-296. PMID: 22197635
  6. Pharmacokinetic profile of raltegravir, elvitegravir and dolutegravir in plasma and mucosal secretions in rhesus macaques.  |  Massud, I., et al. 2015. J Antimicrob Chemother. 70: 1473-81. PMID: 25630643
  7. Effects of raltegravir or elvitegravir resistance signature mutations on the barrier to dolutegravir resistance in vitro.  |  Seki, T., et al. 2015. Antimicrob Agents Chemother. 59: 2596-606. PMID: 25691633
  8. An unexpected interaction between warfarin and cobicistat-boosted elvitegravir.  |  Good, BL., et al. 2015. AIDS. 29: 985-6. PMID: 25909832
  9. HIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination.  |  Nishana, M., et al. 2017. Cell Death Dis. 8: e2852. PMID: 28569776
  10. Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir.  |  Mohideen, M., et al. 2017. Biomaterials. 144: 144-154. PMID: 28829952
  11. Spatial distribution of elvitegravir and tenofovir in rat brain tissue: Application of matrix-assisted laser desorption/ionization mass spectrometry imaging and liquid chromatography/tandem mass spectrometry.  |  Ntshangase, S., et al. 2019. Rapid Commun Mass Spectrom. 33: 1643-1651. PMID: 31240777
  12. Anti-HIV Drug Elvitegravir Suppresses Cancer Metastasis via Increased Proteasomal Degradation of m6A Methyltransferase METTL3.  |  Liao, L., et al. 2022. Cancer Res. 82: 2444-2457. PMID: 35507004
  13. Safety and efficacy of switching to elvitegravir, cobicistat, emtricitabine, tenofovir disoproxil fumarate in treatment-experienced people with HIV: a multicenter cohort study.  |  De Castro, N., et al. 2023. AIDS Res Ther. 20: 1. PMID: 36597160

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Elvitegravir, 10 mg

sc-207615
10 mg
$370.00

It would be great if you could add the solubility information for this.

Asked by: tpietka
Thank you for your question. This compound is soluble in DMSO at a concentration of up to 90 mg/mL (200.94 mM), in ethanol at up to 35 mg/mL (78.14 mM) and is insoluble to very slightly soluble in water - <1 mg/mL (<1 mM).
Answered by: Tech Support Europe
Date published: 2020-08-11

Is Elivitegravir the same chemical as Dolutegravir? I am looking for dolutegravir 10 g

Asked by: Dana S
Thank you for your question. The two compounds are not the same. Dolutegravir has CAS number 1051375-16-6, while Elvitegravir has CAS number 697761-98-1. We offer Dolutegravir under its alternative name, S/GSK1349572, with the corresponding product code sc-364605. Please contact customer care so we can send you a quote for the quantity you require.
Answered by: Tech Support Europe
Date published: 2020-07-30
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Rated 5 out of 5 by from NabekuraNabekura, T. et al. (PubMed 26416870) reported that the antiviral Elvitegravir inhibited organic anion transport in human placental BeWo cells. -SCBT Publication Review
Date published: 2015-05-05
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Elvitegravir is rated 5.0 out of 5 by 1.
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