EF-1 α1 Antibody (CBP-KK1): sc-21758

EF-1 α1 Antibody (CBP-KK1) is a mouse monoclonal IgG1 kappa light chain antibody that detects EF-1 alpha 1 protein of mammalian origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-EF-1 α1 antibody (CBP-KK1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. EF-1 alpha 1 plays a crucial role in protein synthesis as a component of the elongation factor-1 complex, which is essential for delivering aminoacyl tRNAs to the ribosome during translation. This process ensures accurate and efficient protein synthesis, necessary for numerous cellular functions and overall organismal health. EF-1 α1 shows predominant expression in tissues such as brain, placenta, lung, liver, kidney, and pancreas, highlighting widespread physiological importance. Located on chromosome 6q14.1, EF-1 α1 has been identified as an autoantigen in Felty syndrome, a condition characterized by rheumatoid arthritis and increased susceptibility to infections. Understanding EF-1 alpha 1′s function remains essential for researchers studying translation mechanisms and related pathologies.

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EF-1 α1 Antibody (CBP-KK1) References:

1. Possible evolution of factors involved in protein biosynthesis.  |  Nyborg, J. 1998. Acta Biochim Pol. 45: 883-94. PMID: 10397336
2. Translational regulation by modifications of the elongation factor Tu.  |  Kraal, B., et al. 1999. Folia Microbiol (Praha). 44: 131-41. PMID: 10588048
3. GTPases mechanisms and functions of translation factors on the ribosome.  |  Rodnina, MV., et al. 2000. Biol Chem. 381: 377-87. PMID: 10937868
4. Domain III of elongation factor G from Thermus thermophilus is essential for induction of GTP hydrolysis on the ribosome.  |  Martemyanov, KA. and Gudkov, AT. 2000. J Biol Chem. 275: 35820-4. PMID: 10940297
5. Eukaryotic translation elongation factor 1-alpha 1 inhibits p53 and p73 dependent apoptosis and chemotherapy sensitivity.  |  Blanch, A., et al. 2013. PLoS One. 8: e66436. PMID: 23799104
6. Critical role of eukaryotic elongation factor 1 alpha 1 (EEF1A1) in avian reovirus sigma-C-induced apoptosis and inhibition of viral growth.  |  Zhang, Z., et al. 2015. Arch Virol. 160: 1449-61. PMID: 25854689
7. A novel 3'tRNA-derived fragment tRF-Val promotes proliferation and inhibits apoptosis by targeting EEF1A1 in gastric cancer.  |  Cui, H., et al. 2022. Cell Death Dis. 13: 471. PMID: 35585048
8. Nanoparticles (NPs)-mediated lncBCMA silencing to promote eEF1A1 ubiquitination and suppress breast cancer growth and metastasis.  |  Yang, K., et al. 2023. Acta Pharm Sin B. 13: 3489-3502. PMID: 37655325
9. EEF1A1 is Involved the Regulating Neuroinflammatory Processes in Parkinson's Disease.  |  Aisha, Z., et al. 2023. J Integr Neurosci. 22: 122. PMID: 37735116
10. UCHL3 promotes hepatocellular carcinoma progression by stabilizing EEF1A1 through deubiquitination.  |  Zhao, J., et al. 2024. Biol Direct. 19: 53. PMID: 38965582
11. N-Acetylcysteine Inhibits Coxsackievirus B3 Replication by Downregulating Eukaryotic Translation Elongation Factor 1 Alpha 1.  |  Wang, Y., et al. 2024. Viruses. 16: PMID: 39339978
12. Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocation.  |  Agrawal, RK., et al. 1998. Proc Natl Acad Sci U S A. 95: 6134-8. PMID: 9600930

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EF-1 α1 Antibody (CBP-KK1) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-EF-1 α1 Antibody (CBP-KK1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EF-1 α1 Antibody (CBP-KK1) Specifications

Alternate Product Name: EEF1A1

Product Clone Name: CBP-KK1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: EF-1 α1

Epitope Species: Tyrpanosoma brucei

Product Reactivity/Detection: EF-1 α1

Species Reactivity/Detection: mammalian

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for EF-1 α1 Antibody (CBP-KK1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred EF-1 α1/2 antibody is EF-1 α1/2 Antibody (G-8): sc-377439.