Ds(+)-threo-Isocitric acid, trisodium salt (CAS 903507-52-8)
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Ds(+)-threo-Isocitric acid is an anticoagulant that maintains the functionality of platelets. It acts as a buffer for calcium ion activity within the physiological range of approximately 1mM. While it can bypass metabolic blockades and potentially enable heme biosynthesis, it alone is insufficient to reverse the iron-restriction response. Its primary mechanism involves stabilizing the iron-sulfur cluster and is predicted to restore aconitase to its ′high iron′ conformation. As a result, Ds(+)-threo-Isocitric acid dissociates the PKC-associated signaling complexes that become overactive and hinder the responsiveness to erythropoietin (Epo). The compound also binds to isocitrate dehydrogenase (IDH), which, along with aconitase and PKC, may participate in an iron restriction signalosome. Moreover, its contribution to heme biosynthesis likely accounts for its higher effectiveness in promoting erythroid differentiation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ds(+)-threo-Isocitric acid, trisodium salt, 25 mg | sc-364109 | 25 mg | $77.00 | |||
Ds(+)-threo-Isocitric acid, trisodium salt, 100 mg | sc-364109A | 100 mg | $124.00 |