DRAK1 Antibody (3064C6a): sc-81573
- DRAK1 Antibody (3064C6a) is a mouse monoclonal IgG1 DRAK1 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to the C-terminal region of DRAK1 of human origin
- recommended for detection of DRAK1 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DRAK1 Antibody (3064C6a). This work is in progress.
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DRAK1 Antibody (3064C6a) is a mouse monoclonal IgG1 antibody that detects DRAK1 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-DRAK1 antibody (3064C6a) is available as non-conjugated format. DRAK1, or DAP kinase-related apoptosis-inducing protein kinase 1, plays a crucial role in regulating apoptosis, a vital process for maintaining cellular homeostasis and preventing tumorigenesis. DRAK1 is primarily localized in the nucleus, where DRAK1 is involved in signaling pathways that trigger programmed cell death in response to various stressors. Nuclear localization of DRAK1 allows for direct interaction with transcription factors and other nuclear proteins that modulate gene expression related to apoptosis. DRAK1′s ability to induce morphological changes associated with apoptosis in NIH/3T3 cells underscores DRAK1′s importance in cancer biology, as DRAK1 can influence metastatic potential of cells by promoting cell death in response to oncogenic signals. DRAK1 interacts with other members of the DAP kinase family, such as DRAK2, enhancing apoptotic effects and further establishing DRAK1′s role in the intricate network of cellular signaling pathways that govern cell survival and death.
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DRAK1 Antibody (3064C6a) References:
- Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. | Hai, TW., et al. 1989. Genes Dev. 3: 2083-90. PMID: 2516827
- Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. | Deiss, LP., et al. 1995. Genes Dev. 9: 15-30. PMID: 7828849
- DAP kinase links the control of apoptosis to metastasis. | Inbal, B., et al. 1997. Nature. 390: 180-4. PMID: 9367156
- ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. | Kawai, T., et al. 1998. Mol Cell Biol. 18: 1642-51. PMID: 9488481
- Molecular cloning and developmental expression of a rat homologue of death-associated protein kinase in the nervous system. | Sakagami, H. and Kondo, H. 1997. Brain Res Mol Brain Res. 52: 249-56. PMID: 9495546
- DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. | Sanjo, H., et al. 1998. J Biol Chem. 273: 29066-71. PMID: 9786912
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DRAK1 Antibody (3064C6a) | sc-81573 | 100 µg/ml | $333.00 |