Molecular structure of Doripenem monohydrate, CAS Number: 364622-82-2
Doripenem monohydrate (CAS 364622-82-2)
Alternate Names:
Dripenem; (4R,5S,6S)-6-[(1R)-1-Hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Application:
Doripenem monohydrate is a broad spectrum antibiotic belonging to the class of antibiotics called carbapenems
CAS Number:
364622-82-2
Molecular Weight:
438.52
Molecular Formula:
C15H24N4O6S2•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Doripenem monohydrate is a chemically interesting compound, particularly noted for its structure and properties in the realm of synthetic organic chemistry. As a monohydrate, it incorporates a single water molecule into its crystalline structure, which can influence its physical properties such as solubility, stability, and reactivity. The study of Doripenem monohydrate in a hydrated form is significant in the field of crystallography and material science. The incorporation of water into its crystal lattice can affect the compound′s crystal packing, thermal properties, and stability. Analyzing these aspects provides insights into the principles of crystal engineering and the role of hydration in modulating the physical and chemical properties of molecular compounds.
Doripenem monohydrate (CAS 364622-82-2) References
- The UV-derivative spectrophotometry for the determination of doripenem in the presence of its degradation products. | Cielecka-Piontek, J. and Jelińska, A. 2010. Spectrochim Acta A Mol Biomol Spectrosc. 77: 554-7. PMID: 20634123
- Determination of doripenem and related substances in medicinal product using capillary electrophoresis. | Michalska, K., et al. 2011. J Sep Sci. 34: 475-82. PMID: 21298785
- Prolonged infusion of carbapenems in critically ill patients: time to extend our practice. | van Zanten, AR. and van der Meer, YG. 2013. Crit Care Med. 41: 676-7. PMID: 23353954
- Determination of biapenem in a medicinal product by micellar electrokinetic chromatography with sweeping in an enhanced electric field. | Michalska, K., et al. 2013. J Chromatogr A. 1282: 153-60. PMID: 23419350
- New antibiotics for paediatric use: a review of a decade of regulatory trials submitted to the European Medicines Agency from 2000--why aren't we doing better? | Garazzino, S., et al. 2013. Int J Antimicrob Agents. 42: 99-118. PMID: 23810180
- Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance. | Ly, NS., et al. 2015. J Antimicrob Chemother. 70: 1434-42. PMID: 25712313
- Quantitative determination of the β-methyl carbapenem doripenem in powder for injection by a stability-indicating capillary zone electrophoresis method. | Paliosa, PK., et al. 2015. Pharmazie. 70: 569-73. PMID: 26492640
- Stability of doripenem in reconstituted solution - thermal and oxidative decomposition kinetics and degradation products by LC-MS. | de Souza Barbosa, F., et al. 2017. Biomed Chromatogr. 31: PMID: 28135762
- Development and validation of a quantitative confirmatory method for 30 β-lactam antibiotics in bovine muscle using liquid chromatography coupled to tandem mass spectrometry. | Di Rocco, M., et al. 2017. J Chromatogr A. 1500: 121-135. PMID: 28449875
- Improving the chromatographic selectivity of β-lactam residue analysis in milk using phenyl-column chemistry prior to detection by tandem mass spectrometry. | Di Rocco, M., et al. 2020. Anal Bioanal Chem. 412: 4461-4475. PMID: 32447520
- Innovative ultra-sensitive spectrofluorimetric method for nanogram detection of doripenem monohydrate in human plasma, urine and pharmaceutical formulation | Baher I. Salman, Samiha A. Hussein, Marwa F.B. Ali, Mostafa A. Marzouq. 2019. Microchemical Journal. Volume 145: 959-965.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Doripenem monohydrate, 25 mg | sc-396071 | 25 mg | $145.00 |