DnaJB6 Antibody (RQ-6): sc-100710
- DnaJB6 Antibody (RQ-6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant DnaJB6 of human origin
- recommended for detection of DnaJB6 of human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for DnaJB6 Antibody (RQ-6). This work is in progress.
DnaJB6 Antibody (RQ-6) is a mouse monoclonal IgG1 antibody that detects DnaJB6 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). DnaJB6, also known as MRJ, HSJ2, HHDJ1, or MSJ-1, is a member of the DnaJ family of heat shock proteins, which are crucial for maintaining protein homeostasis within the cell. DnaJB6 is predominantly expressed in the brain, where DnaJB6 plays a vital role in neuroprotection and the regulation of protein folding, thereby preventing the aggregation of misfolded proteins that can lead to neurodegenerative diseases. The structure of DnaJB6 includes a J domain that is essential for interaction with HSP 70, facilitating ATP hydrolysis and enhancing the chaperone activity necessary for proper protein maturation. Additionally, DnaJB6 contains cysteine-rich regions that contribute to peptide binding capabilities, further underscoring DnaJB6′s importance in cellular stress responses and protein quality control. Anti-DnaJB6 antibody (RQ-6) enables researchers to gain valuable insights into DnaJB6′s function and implications in various biological processes and diseases.
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DnaJB6 Antibody (RQ-6) References:
- Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer. | Meng, E., et al. 2016. Oncotarget. 7: 53984-53996. PMID: 27276715
- Human DnaJB6 Antiamyloid Chaperone Protects Yeast from Polyglutamine Toxicity Separately from Spatial Segregation of Aggregates. | Kumar, J., et al. 2018. Mol Cell Biol. 38: PMID: 30224519
- Genetic landscape and novel disease mechanisms from a large LGMD cohort of 4656 patients. | Nallamilli, BRR., et al. 2018. Ann Clin Transl Neurol. 5: 1574-1587. PMID: 30564623
- Panorama of the distal myopathies. | Savarese, M., et al. 2020. Acta Myol. 39: 245-265. PMID: 33458580
- Human J-Domain Protein DnaJB6 Protects Yeast from [PSI+] Prion Toxicity. | Dolder, RE., et al. 2022. Biology (Basel). 11: PMID: 36552355
- The roles of HSP40/DNAJ protein family in neurodegenerative diseases. | He, Y. and Wang, Z. 2022. Zhejiang Da Xue Xue Bao Yi Xue Ban. 51: 640-646. PMID: 36581576
- Adaptive preservation of orphan ribosomal proteins in chaperone-dispersed condensates. | Ali, A., et al. 2023. Nat Cell Biol. 25: 1691-1703. PMID: 37845327
- Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription. | Li, Y., et al. 2024. J Bioenerg Biomembr. 56: 171-180. PMID: 38244155
- DNAJB6 is expressed in neurons and oligodendrocytes of the human brain. | Hentze, J., et al. 2024. Glia. 72: 2313-2326. PMID: 39228066
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DnaJB6 Antibody (RQ-6) | sc-100710 | 100 µg/ml | $333.00 |