Diphtheria Toxin
Alternate Names:
Diphtheria Toxin is known as an intact toxin.
Application:
Diphtheria Toxin is an intact toxin catalyst of the ADP-ribosylation of EF-2 and a protein synthesis inhibitor.
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Diphtheria Toxin, from Corynebacterium diphtheriae, inhibits protein synthesis by catalyzing ADP-ribosylation of eukaryotic aminoacyltransferase II (EF-2). Diphtheria Toxin is cell permeable and can translocate across endosomal membranes in response to low pH3. Diphtheria Toxin is synthesized and excreted as a proenzyme and must undergo two covalent alterations in order to be active. LD50 - Intraperitoneal: 0.0065 mg/kg (hamster) 0.0003 mg/kg (mouse). LD50 - Subcutaneous: 0.0003 mg/kg (mouse)
Diphtheria Toxin References
- Biology and molecular epidemiology of diphtheria toxin and the tox gene. | Holmes, RK. 2000. J Infect Dis. 181 Suppl 1: S156-67. PMID: 10657208
- Understanding the mode of action of diphtheria toxin: a perspective on progress during the 20th century. | Collier, RJ. 2001. Toxicon. 39: 1793-803. PMID: 11595641
- Chimeric fusion proteins--diphtheria toxin-based. | Frankel, AE., et al. 2001. Curr Opin Investig Drugs. 2: 1294-301. PMID: 11717818
- Diphtheria toxin translocation across cellular membranes is regulated by sphingolipids. | Spilsberg, B., et al. 2005. Biochem Biophys Res Commun. 329: 465-73. PMID: 15737610
- Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process. | Murphy, JR. 2011. Toxins (Basel). 3: 294-308. PMID: 22069710
- Diphtheria toxin conformational switching at acidic pH. | Leka, O., et al. 2014. FEBS J. 281: 2115-22. PMID: 24628974
- Identification of Formaldehyde-Induced Modifications in Diphtheria Toxin. | Metz, B., et al. 2020. J Pharm Sci. 109: 543-557. PMID: 31678246
- Attenuated diphtheria toxin mediates siRNA delivery. | Arnold, AE., et al. 2020. Sci Adv. 6: PMID: 32917630
- Structure of the Diphtheria Toxin at Acidic pH: Implications for the Conformational Switching of the Translocation Domain. | Rodnin, MV., et al. 2020. Toxins (Basel). 12: PMID: 33171806
- Exploiting the diphtheria toxin internalization receptor enhances delivery of proteins to lysosomes for enzyme replacement therapy. | Sugiman-Marangos, SN., et al. 2020. Sci Adv. 6: PMID: 33310843
- Conformational switching, refolding and membrane insertion of the diphtheria toxin translocation domain. | Ladokhin, AS., et al. 2021. Methods Enzymol. 649: 341-370. PMID: 33712192
- Structures of distant diphtheria toxin homologs reveal functional determinants of an evolutionarily conserved toxin scaffold. | Sugiman-Marangos, SN., et al. 2022. Commun Biol. 5: 375. PMID: 35440624
- A New Combination: Anti Glypican-3 scFv and Diphtheria Toxin with the Best Flexible Linker. | Hashemi Yeganeh, H., et al. 2022. Protein J. 41: 527-542. PMID: 36001255
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Diphtheria Toxin, 1 mg | sc-391135 | 1 mg | $1066.00 |